Evidence map›Paper›PMID 37888594›Full record

ArticleTropical medicine and infectious disease2023

Multiplex Reverse Transcription Polymerase Chain Reaction Combined with a Microwell Hybridization Assay Screening for Arbovirus and Parasitic Infections in Febrile Patients Living in Endemic Regions of Colombia.

Paula Calderon-Ruiz, Gregor Haist, Annina Mascus, Andres F Holguin-Rocha, Philip Koliopoulos, Tim Daniel, Gabriel Velez, Berlin Londono-Renteria, Britta Gröndahl, Alberto Tobon-Castano and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Tropical medicine and infectious disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07727668 (Feasibility Study of Iberdomide), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07727668 early_phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Feasibility Study of Iberdomide (CC-220) Priming to Improve T Cell Fitness Prior to Leukapheresis for Chimeric Antigen Receptor T Cell (CAR-T) Therapy for Relapsed/Refractory Multiple Myeloma (RRMM)

TypeinterventionalSponsorShambavi RichardRan2026 to 2031Enrolled22ConditionsMultiple Myeloma, Relapsed/Refractory Multiple MyelomaArmsIberdomide, CAR-T Leukapheresis, CAR-T Infusion
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Paula Calderon-RuizCenter of Pediatric and Adolescent Medicine, University Medical Center, 55131 Mainz, Germany.
Gregor HaistCenter of Pediatric and Adolescent Medicine, University Medical Center, 55131 Mainz, Germany.
Annina MascusCenter of Pediatric and Adolescent Medicine, University Medical Center, 55131 Mainz, Germany.
Andres F Holguin-RochaDepartment of Entomology, College of Agriculture, Kansas State University, Manhattan, KS 66506, USA.ORCID 0000-0002-1030-0969
Philip KoliopoulosCenter of Pediatric and Adolescent Medicine, University Medical Center, 55131 Mainz, Germany.
Tim DanielCenter of Pediatric and Adolescent Medicine, University Medical Center, 55131 Mainz, Germany.
Gabriel VelezMalaria Group, Lab 610, Faculty of Medicine, University of Antioquia, Medellin 050010, Colombia.ORCID 0000-0002-4859-1124
Berlin Londono-RenteriaSchool of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0001-5956-5274
Britta GröndahlCenter of Pediatric and Adolescent Medicine, University Medical Center, 55131 Mainz, Germany.
Alberto Tobon-CastanoMalaria Group, Lab 610, Faculty of Medicine, University of Antioquia, Medellin 050010, Colombia.
Stephan GehringCenter of Pediatric and Adolescent Medicine, University Medical Center, 55131 Mainz, Germany.
Johannes Gutenberg University Mainz · DEUniversidad de Antioquia · COKansas State University · USTulane University · US

Funding

Else Kröner-Fresenius-Stiftung 81233000Else Kröner-Fresenius-Stiftung 81277525European Union's Horizon 2020 research and innovation program 653316
6 · The paper itself

Abstract

Acute febrile syndrome is a frequent reason for medical consultations in tropical and subtropical countries where the cause could have an infectious origin. Malaria and dengue are the primary etiologies in Colombia. As such, constant epidemiological surveillance and new diagnostic tools are required to identify the causative agents. A descriptive cross-sectional study was conducted to evaluate the circulation and differential diagnosis of six pathogens in two regions of Colombia. The results obtained via multiplex reverse transcription polymerase chain reaction combined with a microwell hybridization assay (m-RT-PCR-ELISA) were comparable to those obtained using rapid tests conducted at the time of patient enrollment. Of 155 patients evaluated, 25 (16.1%) and 16 (10.3%) were positive for malaria and dengue, respectively; no samples were positive for any of the other infectious agents tested. In most cases, m-RT-PCR-ELISA confirmed the results previously obtained through rapid testing.

Indexed as

acute febrile syndromeColombiadenguemalariamultiplex RT-PCR-ELISArapid tests

Identifiers

PMID37888594
PMCPMC10610613
OpenAlexW4387408243

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.