Evidence map›Paper›PMID 37888386›Full record

ArticleGels (Basel, Switzerland)2023

Injectable In Situ Crosslinking Hydrogel for Autologous Fat Grafting.

Kristin Oskarsdotter, Catherine T Nordgård, Peter Apelgren, Karin Säljö, Anita A Solbu, Edwin Eliasson, Sanna Sämfors, Henriette E M Sætrang, Lise Cathrine Asdahl, Eric M Thompson and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gels (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kristin OskarsdotterDepartment of Plastic Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.ORCID 0000-0002-8531-3182
Catherine T NordgårdDepartment of Biotechnology and Food Science, Norwegian Biopolymer Laboratory (NOBIPOL), Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Peter ApelgrenDepartment of Plastic Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.
Karin SäljöDepartment of Plastic Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.ORCID 0000-0002-2839-9362
Anita A SolbuDepartment of Biotechnology and Food Science, Norwegian Biopolymer Laboratory (NOBIPOL), Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Edwin EliassonDepartment of Chemistry and Chemical Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden.
Sanna SämforsDepartment of Chemistry and Chemical Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden.
Henriette E M SætrangDuPont Nutrition Norge AS d/b/a NovaMatrix, Postboks 223, 1377 Billingstad, Norway.
Lise Cathrine AsdahlDuPont Nutrition Norge AS d/b/a NovaMatrix, Postboks 223, 1377 Billingstad, Norway.
Eric M ThompsonOcean TuniCell AS, 5258 Blomsterdalen, Norway.ORCID 0000-0002-3756-9036
Christofer TroedssonOcean TuniCell AS, 5258 Blomsterdalen, Norway.
Stina SimonssonDepartment of Medicinal Chemistry & Cell Biology, Institution of Biomedicine, Sahlgrenska University Hospital, 405 30 Gothenburg, Sweden.
Berit L StrandDepartment of Biotechnology and Food Science, Norwegian Biopolymer Laboratory (NOBIPOL), Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Paul GatenholmCELLHEAL AS, 2636 Sandvika, Norway.
Lars KölbyDepartment of Plastic Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.

Funding

Ann-Mari and Per Ahlqvist Foundation 84000Göteborg Medical Society GLS-882101Inga Britt and Arne Lundberg Research Foundation LU2020-0016, LU2018-0031Magnus Bergvalls Stiftelse 2019-03110Mary von Sydow Foundation 2019-2519Swedish government and the country councils, the ALF-agreement ALFGBG-716621, ALFGBG-971618Swedish Research Council 2021-0097The Research Council of Norway 317790
6 · The paper itself

Abstract

Autologous fat grafting is hampered by unpredictable outcomes due to high tissue resorption. Hydrogels based on enzymatically pretreated tunicate nanocellulose (ETC) and alginate (ALG) are biocompatible, safe, and present physiochemical properties capable of promoting cell survival. Here, we compared in situ and ex situ crosslinking of ETC/ALG hydrogels combined with lipoaspirate human adipose tissue (LAT) to generate an injectable formulation capable of retaining dimensional stability in vivo. We performed in situ crosslinking using two different approaches; inducing Ca

Indexed as

3D bioprintingalginatein situ crosslinkingnanocellulosesoft tissue reconstruction

Identifiers

PMID37888386
PMCPMC10606883

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.