Evidence map›Paper›PMID 37888360›Full record

ArticleGels (Basel, Switzerland)2023

From Poly(glycerol itaconate) Gels to Novel Nonwoven Materials for Biomedical Applications.

Magdalena Miętus, Krzysztof Kolankowski, Tomasz Gołofit, Piotr Denis, Aleksandra Bandzerewicz, Maciej Spychalski, Marcin Mąkosa-Szczygieł, Maciej Pilarek, Kamil Wierzchowski, Agnieszka Gadomska-Gajadhur

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gels (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Magdalena MiętusFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3 Street, 00-664 Warsaw, Poland.ORCID 0000-0002-7634-8594
Krzysztof KolankowskiFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3 Street, 00-664 Warsaw, Poland.ORCID 0000-0003-4684-2652
Tomasz GołofitFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3 Street, 00-664 Warsaw, Poland.ORCID 0000-0001-7594-1145
Piotr DenisLaboratory of Polymers and Biomaterials, Institute of Fundamental Technological Research, Polish Academy of Sciences, Pawińskiego 5B Street, 02-106 Warsaw, Poland.ORCID 0000-0002-1105-3381
Aleksandra BandzerewiczFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3 Street, 00-664 Warsaw, Poland.ORCID 0000-0002-6283-1913
Maciej SpychalskiFaculty of Materials Science and Engineering, Warsaw University of Technology, Wołoska 141 Street, 02-507 Warsaw, Poland.
Marcin Mąkosa-SzczygiełDepartment of Chemistry, Faculty of Natural Sciences, Norwegian University of Science and Technology, 7034 Trondheim, Norway.
Maciej PilarekFaculty of Chemical and Process Engineering, Warsaw University of Technology, Waryńskiego 1 Street, 00-645 Warsaw, Poland.ORCID 0000-0002-8489-0842
Kamil WierzchowskiFaculty of Chemical and Process Engineering, Warsaw University of Technology, Waryńskiego 1 Street, 00-645 Warsaw, Poland.ORCID 0000-0002-7718-0033
Agnieszka Gadomska-GajadhurFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3 Street, 00-664 Warsaw, Poland.ORCID 0000-0001-7686-1745

Funding

National Centre for Research and Development (LIDER/4/0010/L-11/19/NCBR/2020)
6 · The paper itself

Abstract

Electrospinning is a process that has attracted significant interest in recent years. It provides the opportunity to produce nanofibers that mimic the extracellular matrix. As a result, it is possible to use the nonwovens as scaffolds characterized by high cellular adhesion. This work focused on the synthesis of poly(glycerol itaconate) (PGItc) and preparation of nonwovens based on PGItc gels and polylactide. PGItc gels were synthesized by a reaction between itaconic anhydride and glycerol. The use of a mixture of PGItc and PLA allowed us to obtain a material with different properties than with stand-alone polymers. In this study, we present the influence of the chosen ratios of polymers and the OH/COOH ratio in the synthesized PGItc on the properties of the obtained materials. The addition of PGItc results in hydrophilization of the nonwovens' surface without disrupting the high porosity of the fibrous structure. Spectral and thermal analyzes are presented, along with SEM imagining. The preliminary cytotoxicity research showed that nonwovens were non-cytotoxic materials. It also helped to pre-determine the potential application of PGItc + PLA nonwovens as subcutaneous tissue fillers or drug delivery systems.

Indexed as

electrospinninghydrogelspoly(glycerol itaconate)polylactidetissue engineering

Identifiers

PMID37888360
PMCPMC10606113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.