ArticleJournal of personalized medicine2023
Relationship of Medication Intake and Systemic Conditions with Periodontitis: A Retrospective Study.
Article in Journal of personalized medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Effect of framed mHealth messages on oral hygiene and quality of life among Sudanese refugees in Egypt: a randomized controlled trial.BMC oral health · 2026Trial
- Oral Microbiome Signatures in Indonesian Healthy, Gingivitis, and Periodontitis Subjects: A 16S rRNA Next-Generation Sequencing Analysis-Based Exploratory Study.Dentistry journal · 2026Article
- Genomic Evidence on Antihypertensive Drug Targets and Oral Disease Outcomes.Journal of periodontal research · 2026Article
- Effect of renin-angiotensin-aldosterone system inhibitor and statin medication on periodontal status of patients at risk of cardiovascular disease: a systematic review and meta-analysis.The Saudi dental journal · 2026Review
- Dose-dependent association of systemic comorbidities with periodontitis severity: A large population cross-sectional study.Journal of periodontology · 2026Observational
- Chain mediation effects of depressive symptoms and nutritional risk between social support and oral frailty in patients with coronary heart disease.Frontiers in public health · 2026Article
- Periodontopathogens degrade angiotensin I from the human renin-angiotensin system through surface-attached proteases.Scientific reports · 2025Article
- Impact of oral health conditions on the quality of life of hospitalized cardiovascular patients: evidence from Brazil.BMC cardiovascular disorders · 2025Article
- Association Between Common Systemic Medications and the Presence and Severity of Furcation Involvement: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2025Article
- Non-invasive dentistry method for clinical determination of bleeding time: evaluation in subjects with and without direct oral anticoagulant therapy.Thrombosis journal · 2025Article
- Chronic periodontitis in a patient with multiple sclerosis-A case report.Clinical case reports · 2024Article
- Effect of mobile app-based oral hygiene instructions on clinical parameters, oral bacterial diversity, and composition of subgingival microbiota in periodontitis patients.Journal of oral microbiology · 2024Article
- Association of the severity and progression rate of periodontitis with systemic medication intake.Frontiers in oral health · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
objectivesTo examine the potential relationship of medication intake and systemic conditions with periodontitis. METHODS AND MATERIALS: A total of 1985 patient records with a diagnosis of periodontal health and stage III and IV periodontitis were included in the analysis. Demographic characteristics, the number of missing teeth, patient-reported medical conditions and medication intake as well as smoking habits were recorded. Regression models were performed to explore the outcomes.
resultsOlder individuals, Hispanic ethnic groups, Black and Hispanic or Latino racial groups and non-White individuals in general were significantly more frequently diagnosed with periodontitis than health. Hypertension, glaucoma, anxiety and depression were significantly associated with periodontitis, while cancer, alcohol use, kidney problems, asthma, sleep apnea and gastrointestinal disorders were associated with periodontal health. Patients who reported taking anticoagulants, statins and ACE inhibitors demonstrated 3.546 (95% CI: 1.982, 6.343), 2.771 (95% CI: 1.877, 4.09) and 4.847 (95% CI: 2.785, 8.434) times higher odds of having periodontitis, respectively.
conclusionWithin the limitations of this retrospective study that utilized the BigMouth dental data repository, there is a possible relationship between systemic medications including anticoagulants, ACE inhibitors and statins as well as systemic medical conditions including hypertension, glaucoma, anxiety and depression with periodontitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.