ArticleJournal of personalized medicine2023
Macro-TSH: An Uncommon Explanation for Persistent TSH Elevation That Thyroidologists Have to Keep in Mind.
Article in Journal of personalized medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- PEG Precipitation to Detect Macro-TSH in Clinical Practice: A Systematic Review.Clinical endocrinology · 2025Pooled it
- Article
- A subtle initial clinical presentation of a TSH-secreting PitNET.Endocrinology, diabetes & metabolism case reports · 2025Article
- Exploration of post-PEG precipitation TSH recovery in hypothyroid patients.Frontiers in endocrinology · 2025Article
- MacroTSH: still a big problem for clinicians and clinical biochemists: lessons from a case report.European thyroid journal · 2024Article
- Macro-Thyrotropin Syndrome: Prevalence and Clinical Profile of an Under-Recognised Rare Entity in Thyroidology.Indian journal of endocrinology and metabolismArticle
- Real or Not Real? An Elevated TSH.Journal of investigative medicine high impact case reportsArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A macro-thyroid-stimulating hormone (macro-TSH) is an infrequent yet noteworthy phenomenon in the thyroid field. A 69-year-old patient presented with persistently elevated thyroid-stimulating hormone (TSH) levels ranging from 30 to 50 mIU/L, paradoxically accompanied by normal thyroid hormone levels and normal thyroid ultrasound, with no findings on pituitary magnetic resonance. Laboratory studies were conducted to investigate potential interferences impacting the accuracy of TSH measurements. After excluding other potential causes, polyethylene glycol (PEG) precipitation technique was used, which led us to the diagnosis of macro-TSH. This result was confirmed through chromatography. Macro-TSH, although rare, emerged as the key contributor to the patient's unexplained increase in TSH levels. This case highlights the importance of considering macro-TSH as a potential etiology in cases characterized by unexplained TSH elevation, offering insights into diagnostic protocols and expanding our understanding of thyroid function anomalies.
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