ArticleBiomimetics (Basel, Switzerland)2023
Remineralization Induced by Biomimetic Hydroxyapatite Toothpastes on Human Enamel.
Article in Biomimetics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Effects of bleaching agents containing nano-hydroxyapatite on sound and demineralized enamel: an in vitro study.Odontology · 2026Article
- Nano-warfare in the oral cavity: antimicrobial strategies and mechanisms in nanodentistry.Odontology · 2026Review
- Mini review on the synthesis of porous hydroxyapatite nanomaterials for dental tissue engineering.RSC advances · 2026Review
- Enamel Remineralization Potential of Conventional and Biomimetic Toothpaste Formulations: A Comparative In Vitro Study.Dentistry journal · 2026Article
- Evaluation of an orthodontic adhesive containing 2 wt% nano-hydroxyapatite synthesized from a biogenic calcium precursor: antibacterial activity, calcium ion concentration, and enamel demineralization.Biomaterial investigations in dentistry · 2026Article
- The Impact of Calcination on the Structure, Bioactivity, and Biocompatibility of Sol-Gel-Derived Glasses.ACS omega · 2025Article
- The Ways of Forming and the Erosion/Decay/Aging of Bioapatites in the Context of the Reversibility of Apatites.International journal of molecular sciences · 2024Article
- Dentistry and Cranio Facial District: The Role of Biomimetics.Biomimetics (Basel, Switzerland) · 2024Article
- Dynamics of Dental Enamel Surface Remineralization under the Action of Toothpastes with Substituted Hydroxyapatite and Birch Extract.Materials (Basel, Switzerland) · 2024Article
- The Effect of Oral Care Foams and a Spray on Salivary pH Changes after Exposure to Acidic Beverages in Young Adults.Dentistry journal · 2024Article
- Optimization of Functional Toothpaste Formulation Containing Nano-Hydroxyapatite and Birch Extract for Daily Oral Care.Materials (Basel, Switzerland) · 2023Article
- The Evolution of Robin Sequence Treatment Based on the Biomimetic Interdisciplinary Approach: A Historical Review.Biomimetics (Basel, Switzerland) · 2023Review
- Contribution to Knowledge on Bioapatites: Does Mg Level Reflect the Organic Matter and Water Contents of Enamel?International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
This work aimed to compare the effect of four new toothpastes (P1-P4) based on pure and biomimetic substituted nano-hydroxyapatites (HAPs) on remineralization of human enamel. Artificially demineralized enamel slices were daily treated for ten days with different toothpastes according to the experimental design. Tooth enamel surfaces were investigated using atomic force microscope (AFM) images and surface roughness (Ra) determined before and after treatment. The surface roughness of enamel slices was statistically analyzed by one-way ANOVA and Bonferroni's multiple comparison test. X-ray diffraction (XRD) and Fourier transform infrared (FTIR) data revealed the HAP structure with crystal sizes between 28 and 33 nm and crystallinity between 29 and 37%. The average size of HAP particles was found to be between 30 and 40 nm. The Ra values indicated that P3 (HAP-Mg-Zn-Sr-Si) toothpaste was the most effective after 10 days of treatment, leading to the lowest mean roughness. The P3 and P2 (HAP) toothpastes were found to be effective in promoting remineralization. Specifically, their effectiveness can be ranked as follows: P3 = P2 > P4 (HAP-Mg-Zn-Si) > P1 (HAP-Zn), considering both the chemical composition and the size of their constitutive nanoparticles. The proposed toothpastes might be used successfully to treat early tooth decay.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.