Evidence map›Paper›PMID 37887566›Full record

ArticleCurrent oncology (Toronto, Ont.)2023

Evaluation of Anti-Mullerian Hormone Levels, Antral Follicle Counts, and Mean Ovarian Volumes in Chemotherapy-Induced Amenorrhea among Breast Cancer Patients: A Prospective Clinical Study.

Çağlar Ünal, Çetin Ordu, Tolga Özmen, Ahmet Serkan İlgun, Filiz Çelebi, Bülent Baysal, Enver Özkurt, Tomris Duymaz, Zeynep Erdoğan İyigün, Sevgi Kurt and 8 more

Registry-linked trialAbstract read
In one paragraph

Article in Current oncology (Toronto, Ont.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07497191 (A Clinical Model Based on Dynamic Changes in Anti-Müllerian Hormone to Predict Ovarian Reserve in Perimenopausal Breast Cancer Patients), which is not on this map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07497191 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Clinical Model Based on Dynamic Changes in Anti-Müllerian Hormone to Predict Ovarian Reserve in Perimenopausal Breast Cancer Patients

Typeobservational_patient_registrySponsorShengjing HospitalRan2026 to 2030Enrolled300ConditionsBreast Cancer, Perimenopause, Ovarian Reserve
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Çağlar ÜnalDivision of Medical Oncology, Department of Internal Medicine, Kartal Dr. Lütfi Kırdar City Hospital, Istanbul 34865, Turkey.ORCID 0000-0003-3245-1570
Çetin OrduDivision of Medical Oncology, Department of Internal Medicine, Gayrettepe Florence Nightingale Hospital, Istanbul 34349, Turkey.ORCID 0000-0003-4423-8005
Tolga ÖzmenDivision of Gastrointestinal and Oncologic Surgery, Harvard Medical School, Boston, MA 02115, USA.
Ahmet Serkan İlgunDepartment of Surgery, Mater Dei Hospital, Msida, MSD 2090, Malta.
Filiz ÇelebiDepartment of Radiology, Yeditepe University Hospital, Istanbul 34755, Turkey.
Bülent BaysalDepartment of Obstetrics and Gynecology, İstanbul Florence Nightingale Hospital, Istanbul 34381, Turkey.
Enver ÖzkurtDepartment of General Surgery, İstanbul Florence Nightingale Hospital, Istanbul 34381, Turkey.ORCID 0000-0003-2597-3119
Tomris DuymazDepartment of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Istanbul Bilgi University, Istanbul 34060, Turkey.
Zeynep Erdoğan İyigünDepartment of Physical Theraphy and Rehabilitation, Göztepe Medical Park Hospital, Istanbul 34732, Turkey.
Sevgi KurtDepartment of Plastic Surgery, İstanbul Florence Nightingale Hospital, Istanbul 34381, Turkey.
Mehmet Alper ÖztürkDepartment of General Surgery, Biruni Hospital, Istanbul 34295, Turkey.
Kezban Nur PilancıDivision of Medical Oncology, Department of Internal Medicine, Memorial Bahçelievler Hospital, Istanbul 34180, Turkey.
Gül AlçoDepartment of Radiation Oncology, Gayrettepe Florence Nightingale Hospital, Istanbul 34349, Turkey.ORCID 0000-0002-3592-9923
Kanay YararbaşDepartment of Medical Genetics, Demiroglu Bilim University, Istanbul 34394, Turkey.
Tuba Kayan TapanDepartment of Nutrition and Dietetic, Faculty of Health Science, Demiroglu Bilim University, Istanbul 34394, Turkey.
Deniz Can GüvenDivision of Medical Oncology, Department of Internal Medicine, Elazıg Fethi Sekin City Hospital, Elazıg 23280, Turkey.ORCID 0000-0002-6924-9467
Gürsel SoybirDepartment of General Surgery, Memorial Şişli Hospital, Istanbul 34384, Turkey.
Vahit ÖzmenDepartment of General Surgery, İstanbul School of Medicine, İstanbul University, Istanbul 34093, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Estradiol (E2), a follicle-stimulating hormone (FSH), AMH, and inhibin B levels, along with AFC and MOV, are used to determine ovarian reserve in pre-menopausal women. Studies have shown that AMH levels are more sensitive than those of E2, FSH, and inhibin B and that AFC and MOV can be used to evaluate ovarian reserve. AMH, AFC, and MOV measurements were performed before and after adjuvant SC in 3-month periods for one year. Patients were classified as experiencing chemotherapy-induced amenorrhea (CIA) if they did not have menstrual cycles for a period of six months or longer following the conclusion of their chemotherapy treatment. We aimed to evaluate the factors affecting chemotherapy-induced amenorrhea in breast cancer patients treated with adjuvant chemotherapy and the performance of baseline measurements of AMH, AFC, and MOV to predict chemotherapy-induced amenorrhea. The effects of different chemotherapy regimens on the AMH level, AFC, and MOV in CIA patients were investigated. Seventy-one patients were eligible for this study, and the median age was 38 years (range: 23-45). The median follow-up was 37 months (range: 20-51), and CIA developed in 62% of the patients. The AMH level and AFC were significantly decreased one year after SC (

Indexed as

Antineoplastic AgentsBreast NeoplasmsAdultAmenorrheaAnti-Mullerian HormoneFemaleFollicle Stimulating HormoneHumansOvarian FollicleProspective StudiesAnti-Mullerian HormoneAntineoplastic AgentsFollicle Stimulating Hormoneanti-mullerian hormoneantral follicle countsbreast cancerchemotherapy-induced amenorrheamedian ovarian volumesovarian reserve

Identifiers

PMID37887566
PMCPMC10605884

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.