Evidence map›Paper›PMID 37887417›Full record

ArticleMetabolites2023

Metabolomic Profiling of Hormonal Contraceptive Use in Young Females Using a Commercially Available LC-MS/MS Kit.

Tania Grobler, Monique Opperman, Janette Bester, Albe Carina Swanepoel, Ilse du Preez

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Tania GroblerCentre for Human Metabolomics, North-West University, Potchefstroom 2531, South Africa.
Monique OppermanCentre for Human Metabolomics, North-West University, Potchefstroom 2531, South Africa.ORCID 0000-0002-5202-9097
Janette BesterDepartment of Physiology, Faculty of Health Sciences, School of Medicine, University of Pretoria, Pretoria 0002, South Africa.
Albe Carina SwanepoelCentre for Human Metabolomics, North-West University, Potchefstroom 2531, South Africa.
Ilse du PreezCentre for Human Metabolomics, North-West University, Potchefstroom 2531, South Africa.ORCID 0000-0001-5456-3931
North-West University · ZAUniversity of Pretoria · ZA

Funding

DIPLOMICS network N/ANational Research Foundation PSTD220322391
6 · The paper itself

Abstract

Oral hormonal contraceptive users carry the risk of venous thrombosis and increased mortality. This study aimed to comprehensively profile the serum metabolome of participants using a combination of drospirenone (DRSP) and ethinyl estradiol (EE) containing oral contraceptives (COCs). The MxP Quant 500 kit for liquid chromatography mass tandem spectrometry (LC-MS/MS) was used to analyse the 22 controls and 44 COC users (22 on a low EE dose (DRSP/20EE) and 22 on a higher EE dose (DRSP/30EE)). The kit's results were compared to our internally developed untargeted and targeted metabolomics methods previously applied to this cohort. Of the 630 metabolites included in the method, 277 provided desirable results (consistently detected above their detection limits), and of these, 5 had

Indexed as

drospirenoneestradiolhormonal contraceptivesmetabolic profiling

Identifiers

PMID37887417
PMCPMC10609319
OpenAlexW4387776598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.