Evidence map›Paper›PMID 37887332›Full record

ArticleCells2023

Inducing Angiogenesis in the Nucleus Pulposus.

Sheela R Damle, Agata K Krzyzanowska, Maximilian K Korsun, Kyle W Morse, Susannah Gilbert, Han Jo Kim, Oheneba Boachie-Adjei, Bernard A Rawlins, Marjolein C H van der Meulen, Matthew B Greenblatt and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Sheela R DamleHSS Research Institute, Hospital for Special Surgery, 515 E 71st Street, New York, NY 10021, USA.ORCID 0000-0001-6688-0950
Agata K KrzyzanowskaHSS Research Institute, Hospital for Special Surgery, 515 E 71st Street, New York, NY 10021, USA.
Maximilian K KorsunHSS Research Institute, Hospital for Special Surgery, 515 E 71st Street, New York, NY 10021, USA.ORCID 0000-0001-7289-7564
Kyle W MorseHSS Research Institute, Hospital for Special Surgery, 515 E 71st Street, New York, NY 10021, USA.
Susannah GilbertHSS Research Institute, Hospital for Special Surgery, 515 E 71st Street, New York, NY 10021, USA.
Han Jo KimHSS Research Institute, Hospital for Special Surgery, 515 E 71st Street, New York, NY 10021, USA.
Oheneba Boachie-AdjeiHSS Research Institute, Hospital for Special Surgery, 515 E 71st Street, New York, NY 10021, USA.
Bernard A RawlinsHSS Research Institute, Hospital for Special Surgery, 515 E 71st Street, New York, NY 10021, USA.
Marjolein C H van der MeulenHSS Research Institute, Hospital for Special Surgery, 515 E 71st Street, New York, NY 10021, USA.ORCID 0000-0001-6637-9808
Matthew B GreenblattWeill Cornell Medical College, Cornell University, New York, NY 10065, USA.
Chisa HidakaHSS Research Institute, Hospital for Special Surgery, 515 E 71st Street, New York, NY 10021, USA.ORCID 0000-0002-0474-1055
Matthew E CunninghamHSS Research Institute, Hospital for Special Surgery, 515 E 71st Street, New York, NY 10021, USA.ORCID 0000-0003-3723-062X
Hospital for Special Surgery · USCornell University · US

Funding

TRABECULAR BONE ADAPTATION TO MECHANICAL LOADINGP30AR046121 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI BOSKEY, ADELE L · 1999 to 2010
$5.5M
Combined Engineering and Orthopaedics Training ProgramT32AR078751 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI MAHER, SUZANNE A., VAN DER MEULEN, MARJOLEIN C · 2021 to 2025
$1.7M
NIAMS NIH HHS P30 AR046121NIAMS NIH HHS T32 AR078751NIAMS NIH HHS T32-AR078751NIH HHS NIH P30-AR46121
6 · The paper itself

Abstract

Bone morphogenetic protein (BMP) gene delivery to Lewis rat lumbar intervertebral discs (IVDs) drives bone formation anterior and external to the IVD, suggesting the IVD is inhospitable to osteogenesis. This study was designed to determine if IVD destruction with a proteoglycanase, and/or generating an IVD blood supply by gene delivery of an angiogenic growth factor, could render the IVD permissive to intra-discal BMP-driven osteogenesis and fusion. Surgical intra-discal delivery of naïve or gene-programmed cells (BMP2/BMP7 co-expressing or VEGF

Indexed as

Intervertebral DiscNucleus PulposusAnimalsProteoglycansRatsRats, Inbred LewVascular Endothelial Growth Factor AProteoglycansVascular Endothelial Growth Factor Aangiogenesisfusiongene deliveryintervertebral discosteogenesisproteoglycanase nucleus pulposus

Identifiers

PMID37887332
PMCPMC10605635
OpenAlexW4387773232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.