ArticleAntibiotics (Basel, Switzerland)2023
Efficacy of Chlorhexidine after Oral Surgery Procedures on Wound Healing: Systematic Review and Meta-Analysis.
Article in Antibiotics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Expert consensus on the use of oral antiseptics in oral surgery: Evidence-based clinical practice guidelines.Medicina oral, patologia oral y cirugia bucal · 2026Guideline
- Evaluation of the effects of a gel containing green tea and hyaluronic acid on clinical and Microbiological outcomes following periodontal surgery. A randomized, controlled, double-blinded, noninferiority trial.Clinical oral investigations · 2026Trial
- Autogenous Demineralized Dentin Graft With High Molecular Weight Hyaluronic Acid in Ridge Preservation: Pilot Trial.Clinical implant dentistry and related research · 2025Trial
- Topical Antiseptic or Antimicrobial Preparation for Oral Cavity Surgery: Is It Necessary and Does It Help?The Laryngoscope · 2026Article
- Clinical applications of chlorhexidine in oral wound healing: Scoping review of current evidence and research gaps.Medicina oral, patologia oral y cirugia bucal · 2026Article
- A Tailorable and Transferable Flexible Patch for Simultaneous Electrostimulation and Electro-Controlled Drug Delivery in Wound Management.Small science · 2026Article
- The effect of preoperative tizanidine on postoperative pain and trismus following surgical removal of mandibular third molar: A randomized clinical trial.SAGE open medicine · 2026Article
- Rational utilization of antibiotic prophylaxis in oral and maxillofacial surgery: a large scope review of recent data.BMC oral health · 2025Review
- Article
- The Management of a Post-Extraction Gingival Lesion in a Paediatric Patient: A Case Report.Children (Basel, Switzerland) · 2025Article
- Comprehensive Review of Prevention and Management Strategies for Medication-related Osteonecrosis of the Jaw (MRONJ).Oral health & preventive dentistry · 2025Review
- Certainty of evidence on the effects of cryotherapy, surgical wound closure, and chlorhexidine on clinical and patient-centered outcomes after third molar surgery: evidence mapping of systematic reviews and meta-analyses.Medicina oral, patologia oral y cirugia bucal · 2025Article
- Evaluation of the Effect of Aegle marmelos (Bael Leaf) Extract on Human Fibroblast Viability: An In Vitro Study.Cureus · 2024Article
- Enterococcus Phage vB_EfaS_HEf13 as an Anti-Biofilm Agent Against Enterococcus faecalis.Journal of microbiology (Seoul, Korea) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our objective was to evaluate qualitatively and quantitatively, through a systematic review and meta-analysis, available evidence on the efficacy of chlorhexidine (CHX) when applied after oral surgery on wound healing and related clinical parameters. MEDLINE/PubMed, Embase, CENTRAL, Web of Science, and Scopus were searched for studies published before January 2023. The quality of the methodology used in primary-level studies was assessed using the RoB2 tool; meta-analyses were performed jointly with heterogeneity and small-study effect analyses. Thirty-three studies and 4766 cases were included. The results point out that the application of CHX was significantly more effective, compared to controls where CHX was not employed, providing better wound healing after oral surgery (RR = 0.66, 95% CI = 0.55-0.80,
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.