ReviewAntibiotics (Basel, Switzerland)2023
Drug-Induced Acute Pancreatitis in Adults: Focus on Antimicrobial and Antiviral Drugs, a Narrative Review.
Review in Antibiotics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Omadacycline-Associated Pancreatic Injury: a Spectrum from Mild Interstitial to Recrudescent Pancreatitis with Pharmacovigilance Implications.Infectious diseases and therapy · 2026Article
- Nirmatrelvir-Ritonavir-Induced Pancreatitis: A Concern in the COVID Era.ACG case reports journal · 2026Article
- Factors linked to tigecycline-associated acute pancreatitis in a multicenter retrospective nested case-control study in patients.iScience · 2026Article
- A Case of Drug-Induced Pancreatitis.Clinical case reports · 2026Article
- Evaluation of Acute Pancreatitis in Patients Receiving Doxycycline Therapy: A Prospective Study.Cureus · 2026Article
- Molecular, Physiological, and Histopathological Insights into the Protective Role ofLife (Basel, Switzerland) · 2025Article
- A Case of Thiazide-Induced Pancreatitis.Cureus · 2025Article
- Distinguishing Acute Pancreatitis From Refractory Peritonitis in Peritoneal Dialysis: A Case Report.Cureus · 2025Article
- Mesalamine as a Suspected Cause of Drug-Induced Pancreatitis: A Case Report and Review of Diagnostic Considerations.Cureus · 2025Article
- An intriguing case of macrolides-induced pancreatic injury mimicking pancreatic carcinoma.Hepatobiliary surgery and nutrition · 2025Article
- Targeting PFKFB3 to restore glucose metabolism in acute pancreatitis via nanovesicle delivery.Molecular medicine (Cambridge, Mass.) · 2025Article
- [Pancreatitis from drugs-Drugs for treatment of pancreatitis].Innere Medizin (Heidelberg, Germany) · 2025Review
- Possible omadacycline induce acute pancreatitis: a case report and literature review.BMC infectious diseases · 2024Review
- Selective and Concentrative Enteropancreatic Recirculation of Antibiotics by Pigs.Antibiotics (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute pancreatitis (AP) is an acute inflammation of the pancreas caused by the activation of digestive enzymes in the pancreatic tissue. The main causes of AP are cholelithiasis and alcohol abuse; less commonly, it can be caused by drugs, with a prevalence of up to 5%. Causal associations between drugs and pancreatitis are largely based on case reports or case series with limited evidence. We reviewed the available data on drug-induced AP, focusing on antimicrobial drugs and antivirals, and discussed the current evidence in relation to the classification systems available in the literature. We found 51 suspected associations between antimicrobial and antiviral drugs and AP. The drugs with the most evidence of correlation are didanosine, protease inhibitors, and metronidazole. In addition, other drugs have been described in case reports demonstrating positive rechallenge. However, there are major differences between the various classifications available, where the same drug being assigned to different probability classes. It is likely that the presence in multiple case reports of an association between acute pancreatitis and a drug should serve as a basis for conducting prospective randomized controlled trials to improve the quality of the evidence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.