Evidence map›Paper›PMID 37887191›Full record

ArticleAntibiotics (Basel, Switzerland)2023

Monoclonal Antibody Disrupts Biofilm Structure and Restores Antibiotic Susceptibility in an Orthopedic Implant Infection Model.

Zachary D C Burke, Christopher M Hart, Benjamin V Kelley, Zeinab Mamouei, Gideon W Blumstein, Christopher Hamad, Kellyn Hori, Nicolas Cevallos, Christina Villalpando, Nicole Truong and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Monoclonal Antibodies Targeting Bacterial Infections: A Broad Review of the Field.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  6. Conserved CD4Nature microbiology · 2026
    Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Orthopaedic infections: novel treatment strategies and evolving concepts.OTA international : the open access journal of orthopaedic trauma · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Zachary D C BurkeDepartment of Orthopedic Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0001-9601-0956
Christopher M HartDepartment of Orthopedic Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Benjamin V KelleyDepartment of Orthopedic Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-7889-7407
Zeinab MamoueiOrthopedic Hospital Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Gideon W BlumsteinDepartment of Orthopedic Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Christopher HamadOrthopedic Hospital Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-8896-9857
Kellyn HoriOrthopedic Hospital Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Nicolas CevallosOrthopedic Hospital Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Christina VillalpandoOrthopedic Hospital Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Nicole TruongOrthopedic Hospital Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0001-6244-9717
Amr TurkmaniOrthopedic Hospital Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0003-2600-2744
Micah RalstonOrthopedic Hospital Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0009-0008-4220-5529
Aaron KavanaughOrthopedic Hospital Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Edgar TenorioTrellis Bioscience, Inc., Redwood City, CA 94063, USA.
Lawrence M KauvarTrellis Bioscience, Inc., Redwood City, CA 94063, USA.
Alan LiDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-2037-6262
Nathanael PrunetDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA.
Alexandra I StavrakisDepartment of Orthopedic Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Nicholas M BernthalDepartment of Orthopedic Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
University of California, Los Angeles · USTrellis Bioscience (United States) · USCleveland Clinic · US

Funding

Regenerative Musculoskeletal Medicine Training ProgramT32AR059033 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI John S Adams, Nicholas M. Bernthal · 2011 to 2026
$4.8M
Biofilm disrupting antibody to treat respiratory and musculoskeletal infectionsR44AI150143 · NIAID · TRELLIS BIOSCIENCE, INC. · PI KAUVAR, LAWRENCE MICHAEL · 2020 to 2022
$3.0M
Modifying and Delivering Antimicrobials to Prevent Orthopaedic Implant InfectionsK08AR069112 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BERNTHAL, NICHOLAS M. · 2016 to 2019
$704k
NIAID NIH HHS R44 AI150143NIAMS NIH HHS 5K08AR069112-01 and T32AR059033NIAMS NIH HHS K08 AR069112NIAMS NIH HHS T32 AR059033
6 · The paper itself

Abstract

Bacterial biofilms on orthopedic implants are resistant to the host immune response and to traditional systemic antibiotics. Novel therapies are needed to improve patient outcomes. TRL1068 is a human monoclonal antibody (mAb) against a biofilm anchoring protein. For assessment of this agent in an orthopedic implant infection model, efficacy was measured by reduction in bacterial burden of

Indexed as

biofilmmonoclonal antibodyorthopedic implant infectionprosthetic joint infectionS. aureusspinal implant infection

Identifiers

PMID37887191
PMCPMC10604051
OpenAlexW4387140265

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.