Evidence map›Paper›PMID 37887133›Full record

ArticleBiosensors2023

Tapered Fiber Bioprobe Based on U-Shaped Fiber Transmission for Immunoassay.

Xinghong Chen, Lei Xiao, Xuejin Li, Duo Yi, Jinghan Zhang, Hao Yuan, Zhiyao Ning, Xueming Hong, Yuzhi Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xinghong ChenSchool of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.ORCID 0009-0009-4479-3683
Lei XiaoSchool of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
Xuejin LiSchool of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
Duo YiSchool of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
Jinghan ZhangSchool of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
Hao YuanSchool of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
Zhiyao NingSchool of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
Xueming HongSchool of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
Yuzhi ChenSchool of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.ORCID 0000-0002-5975-3053

Funding

High-end Talent Scientific Research Startup Project 827-000636LingChuang Research Project of China National Nuclear Corporation No numberNatural Science Foundation of Guangdong 2021A1515011680Science and Technology plan project of Shenzhen JCYJ20190808145207437Shenzhen Bay Laboratory Open Fund Project SZBL2021080601012
6 · The paper itself

Abstract

In this paper, a tapered fiber bioprobe based on Mach-Zehnder interference (MZI) is proposed. To retain the highly sensitive straight-tapered fiber MZI sensing structure, we designed a U-shaped transmission fiber structure for the collection of optical sensing signals to achieve a miniature-insert-probe design. The spectrum responses from the conventional straight-tapered fiber MZI sensor and our proposed sensor were compared and analyzed, and experimental results showed that our proposed sensor not only has the same sensing capability as the straight-tapered fiber sensor, but also has the advantages of being flexible, convenient, and less liquid-consuming, which are attributed to the inserted probe design. The tapered fiber bioprobe obtained a sensitivity of 1611.27 nm/RIU in the refractive index detection range of 1.3326-1.3414. Finally, immunoassays for different concentrations of human immunoglobulin G were achieved with the tapered fiber bioprobe through surface functionalization, and the detection limit was 45 ng/mL. Our tapered fiber bioprobe has the insert-probe advantages of simpleness, convenience, and fast operation. Simultaneously, it is low-cost, highly sensitive, and has a low detection limit, which means it has potential applications in immunoassays and early medical diagnosis.

Indexed as

Biosensing TechniquesOptical FibersHumansImmunoassayInterferometryRefractometryimmunoassayMach–Zehnder interferenceoptical fiber sensorstapered fiber bioprobes

Identifiers

PMID37887133
PMCPMC10605819

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.