Evidence map›Paper›PMID 37887120›Full record

ArticleBiosensors2023

Surface-Enhanced Raman Scattering Active Core-Shell Ag NPs@Carbon Dots with Enzyme-Mimicking Activities for Label-Free Measurement Cholesterol.

Jian Ju, Lin Li, Bei Li, Sagar Regmi, Tingting Wang, Jiao Xu, Chaojie Li, Shixing Tang

Open access · goldAbstract read
In one paragraph

Article in Biosensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Biomedical Applications of Nanozymes: An Enzymology Perspective.Angewandte Chemie (International ed. in English) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Jian JuWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China.ORCID 0000-0003-4886-0336
Lin LiWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China.
Bei LiSchool of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou 325035, China.
Sagar RegmiDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0001-5104-6613
Tingting WangWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China.
Jiao XuWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China.
Chaojie LiWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China.ORCID 0009-0001-9286-3588
Shixing TangWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China.
University of Chinese Academy of Sciences · CNCase Western Reserve University · USChinese Academy of Sciences · CNWenzhou Medical University · CN

Funding

Basic Research Project of Wenzhou City, China S20220021start-up grant of Wenzhou Institute, University of Chinese Academy of Sciences WIUCASQD2021027Start-up grant of Wenzhou Institute, University of Chinese Academy of Sciences WIUCASQD2020018Zhejiang Provincial Natural Science Foundation of China under grant LTGY23B050002
6 · The paper itself

Abstract

Serological-sensitive testing of cholesterol holds significant value in the fields of healthcare and clinical diagnosis. This study reports on the preparation of peroxidase-mimicking nanozymes through the wrapping of N, S-doped carbon dots (DCDs) on the surface of silver nanoparticles (Ag NPs@DCD). The shell-core structure of Ag NPs@DCD displays peroxidase-mimicking capability, with the potential to catalyze inactive Raman probe molecules into the Raman reporters. Furthermore, a "shell-isolated nanoparticles-enhanced Raman spectroscopy" structure exhibited an enhanced Raman signal of reporter molecules. Ag NPs@DCD were utilized to create a label-free SERS sensing system for high-performance detection of cholesterol in serum samples. These results demonstrate the potential of the novel nanozyme-based SERS approach for clinical diagnosis.

Indexed as

Metal NanoparticlesSpectrum Analysis, RamanCarbonCharcoalGoldPeroxidaseSilverCarbonCharcoalGoldPeroxidaseSilvercholesteroldoped carbon dotslabel-free assayperoxidase-mimickingsilver nanocompositeSurface-enhanced Raman Spectroscopy (SERS)

Identifiers

PMID37887120
PMCPMC10605028
OpenAlexW4387670347

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.