ReviewAdvances in respiratory medicine2023
Cardiogenic Pulmonary Edema in Emergency Medicine.
Review in Advances in respiratory medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Pooled it
- Pooled it
- High Altitude Pulmonary Edema Response to Continuous Airway Positive Pressure: A Randomized Controlled Trial: The HAPER CAPER Trial.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2025Trial
- Ultrasonographic Assessment of the Lungs in Asiatic Elephants (Elephas maximus).Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2026Article
- Diagnostic and Prognostic Value of Arterial Blood Gas and Electrolyte Analyses in Heart Failure.Reviews in cardiovascular medicine · 2026Review
- Respiratory Support in Cardiogenic Pulmonary Edema: Clinical Insights from Cardiology and Intensive Care.Journal of cardiovascular development and disease · 2026Review
- Single chiral center epimerization-modulated multi-carrier-free oral hydrogel for remolding inflammatory microenvironment via PI3K/Akt/NF-κB and MAPK signaling pathways.Bioactive materials · 2026Article
- Finite element modeling of human thorax for electrical bioimpedance based monitoring of pulmonary fluid accumulation.Journal of electrical bioimpedance · 2026Article
- Post-Treatment Partial Pressure of Carbon Dioxide for Prognostic Stratification and Non-Invasive Ventilation Guidance in Elderly Patients with Community-Acquired Pneumonia and Heart Failure: The "Subgroup with Impaired Cardiac Response".International journal of general medicine · 2026Article
- Modern management of maxillofacial trauma in the emergency department.World journal of emergency medicine · 2026Review
- Clinical characteristics and outcomes of neonatal heart failure: a single-center retrospective analysis.Frontiers in pediatrics · 2026Article
- Association between preserved ratio impaired spirometry and cardiovascular disease subtypes: evidence from NHANES 2007-2012.BMC cardiovascular disorders · 2025Article
- Derivation and validation of a simple prognostic risk score to predict short-term mortality in acute cardiogenic pulmonary edema: the SABIHA score.Clinical and experimental emergency medicine · 2025Article
- Use of Continuous Positive Airway Pressure Ventilation as a Support During Coronary Angioplasty in Patients with Acute Myocardial Infarction: Safety and Feasibility.Journal of clinical medicine · 2025Article
- Clinical Pharmacology of Loop Diuretics in Critical Care.Clinical pharmacokinetics · 2025Review
- Assessment of Pulmonary Vein Diameters in Cavalier King Charles Spaniels with Myxomatous Mitral Valve Disease.Veterinary sciences · 2025Article
- Tissue Doppler Imaging in Acute and Critical Care: Enhancing Diagnostic Precision.Medicina (Kaunas, Lithuania) · 2025Review
- The diagnostic performance of automatic B-lines detection for evaluating pulmonary edema in the emergency department among novice point-of-care ultrasound practitioners.Emergency radiology · 2025Article
- High-flow vs conventional oxygen therapies for acute cardiogenic pulmonary edema following hip fractures and surgery in elderly patients.Frontiers in oncology · 2025Article
- Application of a modified lung ultrasound score in assessing the severity of neonatal pneumonia: a multicenter prospective study.Frontiers in medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiogenic pulmonary edema (CPE) is characterized by the development of acute respiratory failure associated with the accumulation of fluid in the lung's alveolar spaces due to an elevated cardiac filling pressure. All cardiac diseases, characterized by an increasing pressure in the left side of the heart, can cause CPE. High capillary pressure for an extended period can also cause barrier disruption, which implies increased permeability and fluid transfer into the alveoli, leading to edema and atelectasis. The breakdown of the alveolar-epithelial barrier is a consequence of multiple factors that include dysregulated inflammation, intense leukocyte infiltration, activation of procoagulant processes, cell death, and mechanical stretch. Reactive oxygen and nitrogen species (RONS) can modify or damage ion channels, such as epithelial sodium channels, which alters fluid balance. Some studies claim that these patients may have higher levels of surfactant protein B in the bloodstream. The correct approach to patients with CPE should include a detailed medical history and a physical examination to evaluate signs and symptoms of CPE as well as potential causes. Second-level diagnostic tests, such as pulmonary ultrasound, natriuretic peptide level, chest radiograph, and echocardiogram, should occur in the meantime. The identification of the specific CPE phenotype is essential to set the most appropriate therapy for these patients. Non-invasive ventilation (NIV) should be considered early in the treatment of this disease. Diuretics and vasodilators are used for pulmonary congestion. Hypoperfusion requires treatment with inotropes and occasionally vasopressors. Patients with persistent symptoms and diuretic resistance might benefit from additional approaches (i.e., beta-agonists and pentoxifylline). This paper reviews the pathophysiology, clinical presentation, and management of CPE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.