Evidence map›Paper›PMID 37887038›Full record

ArticleBiology2023

Klotho Null Mutation Indirectly Leads to Age-Related Lacrimal Gland Degeneration in Mutant Mice.

Chun-Yen Wu, Da-Fong Song, Tsung-Han Lu, Zhi-Jia Chen, Su-Min Tsai, Ya-Jing Liu, Han-Hsin Chang, David Pei-Cheng Lin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chun-Yen WuDepartment of Nutrition, Chung Shan Medical University, Taichung City 402, Taiwan.ORCID 0009-0008-6332-181X
Da-Fong SongDepartment of Nutrition, Chung Shan Medical University, Taichung City 402, Taiwan.
Tsung-Han LuDepartment of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung City 402, Taiwan.
Zhi-Jia ChenDepartment of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung City 402, Taiwan.ORCID 0009-0005-2317-5668
Su-Min TsaiDepartment of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung City 402, Taiwan.
Ya-Jing LiuDepartment of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung City 402, Taiwan.
Han-Hsin ChangDepartment of Nutrition, Chung Shan Medical University, Taichung City 402, Taiwan.
David Pei-Cheng LinDepartment of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung City 402, Taiwan.ORCID 0000-0002-8658-9703
Chung Shan Medical University · TWChung Shan Medical University Hospital · TW

Funding

Chung Shan Medical University CSMU-INT-102-07Ministry of Science and Technology, Taiwan MOST 110-2320-B-040-022
6 · The paper itself

Abstract

The Klotho null mutation is known to lead to accelerated aging in many organs, but its effects on tear secretion and lacrimal gland (LG) senescence have not been addressed. This study investigated whether the Klotho null mutation would lead to a dry eye status and the outcome of LG without Klotho function. The Klotho (

Indexed as

acinar atrophyage-related dry eye diseaseKlotho mutationlacrimal gland degenerationmurine modeltear volume

Identifiers

PMID37887038
PMCPMC10604155
OpenAlexW4387576757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.