Evidence map›Paper›PMID 37886984›Full record

ReviewBiology2023

The Basolateral Amygdala: The Core of a Network for Threat Conditioning, Extinction, and Second-Order Threat Conditioning.

Tayebeh Sepahvand, Kyron D Power, Tian Qin, Qi Yuan

Open access · goldAbstract readReview
In one paragraph

Review in Biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Tayebeh SepahvandBiomedical Sciences, Faculty of Medicine, Memorial University, St John's, NL A1B 3V6, Canada.ORCID 0009-0003-2030-6947
Kyron D PowerBiomedical Sciences, Faculty of Medicine, Memorial University, St John's, NL A1B 3V6, Canada.ORCID 0009-0009-6411-3702
Tian QinBiomedical Sciences, Faculty of Medicine, Memorial University, St John's, NL A1B 3V6, Canada.ORCID 0000-0001-7196-1843
Qi YuanBiomedical Sciences, Faculty of Medicine, Memorial University, St John's, NL A1B 3V6, Canada.ORCID 0000-0002-9837-8495
Memorial University of Newfoundland · CA

Funding

Natural Sciences and Engineering Research Council RGPIN-2018-04401
6 · The paper itself

Abstract

Threat conditioning, extinction, and second-order threat conditioning studied in animal models provide insight into the brain-based mechanisms of fear- and anxiety-related disorders and their treatment. Much attention has been paid to the role of the basolateral amygdala (BLA) in such processes, an overview of which is presented in this review. More recent evidence suggests that the BLA serves as the core of a greater network of structures in these forms of learning, including associative and sensory cortices. The BLA is importantly regulated by hippocampal and prefrontal inputs, as well as by the catecholaminergic neuromodulators, norepinephrine and dopamine, that may provide important prediction-error or learning signals for these forms of learning. The sensory cortices may be required for the long-term storage of threat memories. As such, future research may further investigate the potential of the sensory cortices for the long-term storage of extinction and second-order conditioning memories.

Indexed as

amygdaladopamineextinctionhippocampusnorepinephrineprefrontal cortexsecond-order conditioningsensory cortexthreat conditioning

Identifiers

PMID37886984
PMCPMC10604397
OpenAlexW4386967598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.