ArticleCirculation. Heart failure2023
Obesity Modifies Clinical Outcomes of Right Ventricular Dysfunction.
Article in Circulation. Heart failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Insulin Resistance Indices and Subclinical Left Ventricular Systolic Dysfunction in Adults: A Systematic Review and Meta-Analysis.Reviews in cardiovascular medicine · 2026Pooled it
- Even short-term obesity leads to subclinical dysfunction of both ventricles in young individuals.Wiener klinische Wochenschrift · 2026Article
- Airway management in critically ill patients with obesity.Intensive care medicine · 2026Review
- Mechanical ventilation for ICU patient with obesity: current best practices and future directions.Intensive care medicine · 2026Review
- Mechanisms of GLP-1 Receptor Agonists in HFpEF: Exploring Weight-Dependent and Independent Drivers of Therapeutic Benefit.Circulation. Heart failure · 2026Review
- Challenges and opportunities in assessing right ventricular structure and function: a Roadmap for standardization, clinical implementation and research.Nature reviews. Cardiology · 2026Review
- Acute Heart Failure in Heart Failure with Preserved Ejection Fraction: A State-of-the-art Review from an International Expert Group.Cardiac failure review · 2026Review
- Relationship Between Right Ventricular Function and Body Composition in Adolescents and Young Adults.Diagnostics (Basel, Switzerland) · 2025Article
- Sex-Specific Disparities in the Female Vs Male Patient Population in Left Ventricular Assist Device Use.CJC open · 2025Review
- The Impact of Insulin Resistance on Lung Volume Through Right Ventricular Dysfunction in Diabetic Patients-Literature Review.Journal of personalized medicine · 2025Review
- Body Mass Index and Right Ventricular Structure: Insights From Observational and Mendelian Randomization Analyses.Pulmonary circulation · 2025Article
- Association between triglyceride glucose-body mass index and long-term adverse outcomes in individuals with heart failure: a retrospective cohort study.Frontiers in nutrition · 2025Article
- Impairment in Right Ventricular-Pulmonary Arterial Coupling in Overweight and Obesity.Journal of clinical medicine · 2024Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundRight ventricular (RV) dysfunction is associated with increased mortality across a spectrum of cardiovascular diseases. The role of obesity in RV dysfunction and adverse outcomes is unclear.
methodsWe examined patients undergoing right heart catheterization between 2005 and 2016 in a hospital-based cohort. Linear regression was used to examine the association of obesity with hemodynamic indices of RV dysfunction (pulmonary artery pulsatility index, right atrial pressure:pulmonary capillary wedge pressure ratio, RV stroke work index). Cox models were used to examine the association of RV function measures with clinical outcomes.
resultsAmong 8285 patients (mean age, 63 years; 40% women), higher body mass index was associated with worse indices of RV dysfunction, including lower pulmonary artery pulsatility index (β, -0.23; SE, 0.01;
conclusionsPatients with obesity had worse hemodynamic measured indices of RV function across a broad hospital-based sample. While RV dysfunction was associated with worse clinical outcomes including mortality and heart failure hospitalization, this association was especially pronounced among individuals with higher body mass index.
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Registered trials
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