Evidence map›Paper›PMID 37886663›Full record

ArticleFrontiers in cellular and infection microbiology2023

Study of the antimicrobial activity of cationic carbosilane dendrimers against clinical strains of multidrug-resistant bacteria and their biofilms.

Marcos Hernando-Gozalo, John Jairo Aguilera-Correa, Carlos Rescalvo-Casas, Laura Seijas-Pereda, Carlos García-Bertolín, Francisco Javier de la Mata, Javier Sánchez-Nieves, Juan Cuadros, Ramón Pérez-Tanoira

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marcos Hernando-GozaloUniversity of Alcalá, Department of Organic and Inorganic Chemistry, Research Institute in Chemistry "Andrés M. del Río" (IQAR), Madrid, Spain.
John Jairo Aguilera-CorreaClinical Microbiology Department, Instituto de Investigación Sanitaria (IIS)-Fundacion Jimenez Diaz-Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Carlos Rescalvo-CasasUniversity of Alcalá, Department of Biomedicine and Biotechnology, Faculty of Medicine, Madrid, Spain.
Laura Seijas-PeredaUniversity of Alcalá, Department of Biomedicine and Biotechnology, Faculty of Medicine, Madrid, Spain.
Carlos García-BertolínClinical Microbiology Department, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Spain.
Francisco Javier de la MataUniversity of Alcalá, Department of Organic and Inorganic Chemistry, Research Institute in Chemistry "Andrés M. del Río" (IQAR), Madrid, Spain.
Javier Sánchez-NievesUniversity of Alcalá, Department of Organic and Inorganic Chemistry, Research Institute in Chemistry "Andrés M. del Río" (IQAR), Madrid, Spain.
Juan CuadrosUniversity of Alcalá, Department of Biomedicine and Biotechnology, Faculty of Medicine, Madrid, Spain.
Ramón Pérez-TanoiraUniversity of Alcalá, Department of Biomedicine and Biotechnology, Faculty of Medicine, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Antimicrobial Resistance is a serious public health problem, which is aggravated by the ability of the microorganisms to form biofilms. Therefore, new therapeutic strategies need to be found, one of them being the use of cationic dendritic systems (dendrimers and dendrons). Methods: The aim of this study is to analyze the Results: All the tested compounds showed Discussion: Our study demonstrates the possibility of using the four compounds mentioned above as possible topical antimicrobials against the clinical and reference strains of multidrug-resistant bacteria.

Indexed as

Anti-Infective AgentsDendrimersMethicillin-Resistant Staphylococcus aureusAnthracenesAnti-Bacterial AgentsBiofilmsHeLa CellsHumansMicrobial Sensitivity TestsSilanesAnthracenesAnti-Bacterial AgentsAnti-Infective AgentscarbosilaneDendrimersdendronSilanesantibacterialbiofilmscarbosilane dendrimers and dendronsmultiresistant bacteriaquaternary ammonium salts

Identifiers

PMID37886663
PMCPMC10598583

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.