Evidence map›Paper›PMID 37886586›Full record

ArticleResearch square2023

An integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D associated genes and regulatory signals.

Zeping Zhao, Ricardo D'Oliveira Albanus, Henry Taylor, Xuming Tang, Yuling Han, Peter Orchard, Arushi Varshney, Tuo Zhang, Nandini Manickam, Mike Erdos and 11 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 12 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 1 country.

Zeping ZhaoDepartment of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.
Ricardo D'Oliveira AlbanusDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-3651-0136
Henry TaylorCenter for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-2088-5240
Xuming TangDepartment of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.
Yuling HanDepartment of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.
Peter OrchardDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Arushi VarshneyDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-9177-9707
Tuo ZhangStem Cell Research Facility, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.ORCID 0000-0001-5396-918X
Nandini ManickamDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Mike ErdosCenter for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-6603-1833
Narisu NarisuCenter for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-8483-1156
Leland TaylorCenter for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Xiaxia SaavedraDepartment of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.
Aaron ZhongGenomic Resource Core Facility, Weill Cornell Medical College, NY 10065, USA.
Bo LiDepartment of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.
Ting ZhouGenomic Resource Core Facility, Weill Cornell Medical College, NY 10065, USA.ORCID 0000-0003-1423-1507
Ali NajiDepartment of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA19104, USA.
Chengyang LiuDepartment of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA19104, USA.
Francis CollinsCenter for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-1023-7410
Stephen Cj ParkerDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-8122-0117
Shuibing ChenDepartment of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.ORCID 0000-0002-6294-5187
Cornell University · USNational Institutes of Health · USUniversity of Michigan · USHospital of the University of Pennsylvania · USMemorial Sloan Kettering Cancer Center · USUniversity of Pennsylvania · US

Funding

Human Pancreas Analysis Program for Type 1 Diabetes - HPAP-T1DU01DK112217 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MARK A. ATKINSON, KLAUS H KAESTNER · 2021 to 2026
$46.8M
Genetic analysis of type II diabetes in Finnish populationZIAHG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ERDOS, MICHAEL · 2009 to 2025
$38.2M
GENETIC ANALYSIS OF TYPE II DIABETES IN FINNISH POPULATIONZ01HG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI COLLINS, FRANCIS S. · 1995 to 2008
$6.2M
Determining the Intrinsic and Environmental Signal Contributing to Early T1D ProgressionU01DK127777 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN, SHUIBING, PARKER, STEPHEN CJ · 2020 to 2023
$3.0M
Intramural NIH HHS Z01 HG000024Intramural NIH HHS ZIA HG000024NIDDK NIH HHS U01 DK112217NIDDK NIH HHS U01 DK127777
6 · The paper itself

Abstract

Genome wide association studies (GWAS) have identified over 100 signals associated with type 1 diabetes (T1D). However, translating any given T1D GWAS signal into mechanistic insights, including putative causal variants and the context (cell type and cell state) in which they function, has been limited. Here, we present a comprehensive multi-omic integrative analysis of single-cell/nucleus resolution profiles of gene expression and chromatin accessibility in healthy and autoantibody

Identifiers

PMID37886586
PMCPMC10602166
OpenAlexW4387730875

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.