Evidence map›Paper›PMID 37886574›Full record

ArticleResearch square2023

GPR55 is expressed in glutamate neurons and functionally modulates nicotine taking and seeking in rats and mice.

Zheng-Xiong Xi, Yi He, Hui Shen, Guo-Hua Bi, Hai-Ying Zhang, Omar Soler-Cedeno, Hannah Alton, Yihong Yang

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zheng-Xiong XiNational Institute on Drug Abuse.ORCID 0000-0001-6482-8104
Yi HeNational Institute on Drug Abuse.
Hui ShenNational Institute on Drug Abuse.
Guo-Hua BiNational Institute on Drug Abuse.
Hai-Ying ZhangNational Institute on Drug Abuse.
Omar Soler-CedenoNational Institute on Drug Abuse.
Hannah AltonNational Institute on Drug Abuse.
Yihong YangNational Institute on Drug Abuse.
National Institute on Drug Abuse · US

Funding

Cannabinoid CB1 and CB2 receptors and drug abuseZIADA000633 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI XI, ZHENG-XIONG · 2023 to 2025
$3.1M
Function of the Parabrachial Nucleus to Central Amydala Pathway in Pain-Related PlasticityFI2GM138065 · NIGMS · U.S. NAT'L INST/DENTAL/CRANIOFACIAL RES · PI SOLER-CEDENO, OMAR · 2020 to 2020
–
Intramural NIH HHS ZIA DA000633NIGMS NIH HHS FI2 GM138065
6 · The paper itself

Abstract

Cannabis legalization continues to progress in the USA for medical and recreational purposes. G protein-coupled receptor 55 (GPR55) is a putative "CB3" receptor. However, its functional role in cannabinoid action and drug abuse is not explored. Here we report that GPR55 is mainly expressed in cortical and subcortical glutamate neurons and its activation attenuates nicotine taking and seeking in rats and mice. RNAscope

Indexed as

cocainedopamine neuronsglutamate neuronsGPR55nicotinerewardself-administrationΔ9-tetrahydrocannabinol

Identifiers

PMID37886574
PMCPMC10602186
OpenAlexW4387303219

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.