Evidence map›Paper›PMID 37886562›Full record

ArticleResearch square2023

NK Receptors Replace CD28 As the Dominant Source of Signal 2 for Cognate Recognition of Cancer Cells by TAA-specific Effector CD8

Bowen Dong, Nataša Obermajer, Takemasa Tsuji, Junko Matsuzaki, Cindy Bonura, Henry Withers, Mark Long, Colin Chavel, Scott H Olejniczak, Hans Minderman and 4 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Bowen DongDepartment of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.ORCID 0000-0001-9895-2496
Nataša ObermajerDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.ORCID 0000-0002-0838-7508
Takemasa TsujiDepartment of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
Junko MatsuzakiDepartment of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
Cindy BonuraDepartment of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
Henry WithersDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
Mark LongDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
Colin ChavelDepartment of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
Scott H OlejniczakDepartment of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.ORCID 0000-0001-6857-5554
Hans MindermanFlow and Immune Analysis Shared Resource, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
Robert P EdwardsDepartment of OB-GYN, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Walter J StorkusDepartment of Dermatology , University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Pedro RomeroUniversity of Lausanne and Ludwig Institute for Cancer Research, Lausanne, Switzerland.
Pawel KalinskiDepartment of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
Roswell Park Comprehensive Cancer Center · USUniversity of Chicago · USUniversity of Pittsburgh · USJanssen (Belgium) · BE

Funding

RPCI-UPCI Ovarian Cancer SPOREP50CA159981 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MOYSICH, KIRSTEN B., ODUNSI, KUNLE · 2013 to 2025
$19.6M
Targeting the Chemokine System to Sensitize Tumors to ImmunotherapyP01CA234212 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI KALINSKI, PAWEL · 2020 to 2024
$10.1M
Associate-Director Flow and Image Cytometry Roswell Park ComprehensiveCancer CenterR50CA211108 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI HANS MINDERMAN · 2016 to 2026
$3.0M
Understanding mechanisms and consequences of T cell co-receptor regulated RNA maturationR01AI155499 · NIAID · ROSWELL PARK CANCER INSTITUTE CORP · PI OLEJNICZAK, SCOTT HENRY · 2021 to 2025
$2.6M
NCI NIH HHS P01 CA234212NCI NIH HHS P50 CA159981NCI NIH HHS R50 CA211108NIAID NIH HHS R01 AI155499
6 · The paper itself

Abstract

CD28-driven "signal 2" is critical for naïve CD8

Identifiers

PMID37886562
PMCPMC10602189
OpenAlexW4387732918

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.