Evidence map›Paper›PMID 37886546›Full record

ArticleResearch square2023

Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet.

Lorenzo Leggio, Andras Leko, Adriana Gregory-Flores, Renata Marchette, Juan Gomez, Janaina Vendruscolo, Vez Repunte-Canonigo, Vicky Chuong, Sara Deschaine, Kimberly Whiting and 12 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 6 institutions in 2 countries.

Lorenzo LeggioNational Institutes of Health.
Andras LekoNational Institutes of Health.
Adriana Gregory-FloresNational Institutes of Health.
Renata MarchetteNational Institutes on Alcohol Abuse and Alcoholism.ORCID 0000-0001-5040-7966
Juan GomezNIH.
Janaina VendruscoloNational Institute on Drug Abuse.
Vez Repunte-CanonigoThe Scripps Research Institute.
Vicky ChuongNational Institutes of Health.ORCID 0000-0002-1996-8164
Sara DeschaineNational Institutes of Health.
Kimberly WhitingNational Institutes of Health.
Shelley JacksonNational Institute on Drug Abuse.
Maria CornejoInstituto Multidisciplinario de Biología Celular.
Mario PerelloInstituto Multidisciplinario de Biología Celular.
Zhi-Bing YouNational Institutes of Health.
Michael EckhausNIH.
Kim JandaThe Scripps Research Institute.ORCID 0000-0001-6759-4227
Barry ZormanBaylor College of Medicine.
Pavel SumazinBaylor College of Medicine.ORCID 0000-0002-1215-4977
George KoobNational Institute on Drug Abuse.
Michael MichaelidesNIH.ORCID 0000-0003-0398-4917
Pietro Paolo SannaThe Scripps Research Institute.ORCID 0000-0002-8307-2151
Leandro VendruscoloNational Institute on Drug Abuse.ORCID 0000-0002-8829-8627
National Institutes of Health · USScripps Research Institute · USNational Institute on Drug Abuse · USBaylor College of Medicine · USInstituto Multidisciplinario de Biología Celular · ARNational Institute on Alcohol Abuse and Alcoholism · US

Funding

Alcohol-Induced Neuroinflammation and AUD Therapeutic MechanismsR01AA028982 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI Vez REPUNTE-CANONIGO, PIETRO P SANNA · 2022 to 2026
$2.0M
NIAAA NIH HHS R01 AA028982
6 · The paper itself

Abstract

The stomach-derived hormone ghrelin regulates essential physiological functions. The ghrelin receptor (GHSR) has ligand-independent actions, therefore,

Identifiers

PMID37886546
PMCPMC10602167
OpenAlexW4387744193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.