Evidence map›Paper›PMID 37886541›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Cortical lesions uniquely predict motor disability accrual and form rarely in the absence of new white matter lesions in multiple sclerosis.

Erin S Beck, W Andrew Mullins, Jonadab Dos Santos Silva, Stefano Filippini, Prasanna Parvathaneni, Josefina Maranzano, Mark Morrison, Daniel J Suto, Corinne Donnay, Henry Dieckhaus and 12 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 3 countries.

Erin S BeckNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
W Andrew MullinsNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Jonadab Dos Santos SilvaDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Stefano FilippiniNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Prasanna ParvathaneniNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Josefina MaranzanoMcConnell Brain Imaging Centre, Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Mark MorrisonNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Daniel J SutoNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Corinne DonnayNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Henry DieckhausNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Nicholas J LucianoNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Kanika SharmaNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
María Ines GaitánNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Jiaen LiuNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Jacco A de ZwartNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Peter van GelderenNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Irene CorteseNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Sridar NarayananMcConnell Brain Imaging Centre, Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Jeff H DuynNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Govind NairDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Pascal SatiNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Daniel S ReichNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
National Institutes of Health · USIcahn School of Medicine at Mount Sinai · USMontreal Neurological Institute and Hospital · CACedars-Sinai Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and objectives: Cortical lesions (CL) are common in multiple sclerosis (MS) and associate with disability and progressive disease. We asked whether CL continue to form in people with stable white matter lesions (WML) and whether the association of CL with worsening disability relates to pre-existing or new CL. Methods: A cohort of adults with MS were evaluated annually with 7 tesla (T) brain magnetic resonance imaging (MRI) and 3T brain and spine MRI for 2 years, and clinical assessments for 3 years. CL were identified on 7T images at each timepoint. WML and brain tissue segmentation were performed using 3T images at baseline and year 2. Results: 59 adults with MS had ≥1 7T follow-up visit (mean follow-up time 2±0.5 years). 9 had "active" relapsing-remitting MS (RRMS), defined as new WML in the year prior to enrollment. Of the remaining 50, 33 had "stable" RRMS, 14 secondary progressive MS (SPMS), and 3 primary progressive MS. 16 total new CL formed in the active RRMS group (median 1, range 0-10), 7 in the stable RRMS group (median 0, range 0-5), and 4 in the progressive MS group (median 0, range 0-1) (p=0.006, stable RR vs PMS p=0.88). New CL were not associated with greater change in any individual disability measure or in a composite measure of disability worsening (worsening Expanded Disability Status Scale or 9-hole peg test or 25-foot timed walk). Baseline CL volume was higher in people with worsening disability (median 1010μl, range 13-9888 vs median 267μl, range 0-3539, p=0.001, adjusted for age and sex) and in individuals with RRMS who subsequently transitioned to SPMS (median 2183μl, range 270-9888 vs median 321μl, range 0-6392 in those who remained RRMS, p=0.01, adjusted for age and sex). Baseline WML volume was not associated with worsening disability or transition from RRMS to SPMS. Discussion: CL formation is rare in people with stable WML, even in those with worsening disability. CL but not WML burden predicts future worsening of disability, suggesting that the relationship between CL and disability progression is related to long-term effects of lesions that form in the earlier stages of disease, rather than to ongoing lesion formation.

Identifiers

PMID37886541
PMCPMC10602044
OpenAlexW4386990191

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.