Evidence map›Paper›PMID 37886530›Full record

ArticleResearch square2023

An immune-competent human gut microphysiological system enables inflammation-modulation of

Jianbo Zhang, Yu-Ja Huang, Martin Trapecar, Charles Wright, Kirsten Schneider, John Kemmit, Victor Hernandez-Gordillo, Jun Young Yoon, Eric J Alm, David T Breault and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Jianbo ZhangDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0003-3526-4586
Yu-Ja HuangDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Martin TrapecarDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Charles WrightDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Kirsten SchneiderDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
John KemmitDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Victor Hernandez-GordilloDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Jun Young YoonDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Eric J AlmDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
David T BreaultDepartment of Pediatrics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0402-4857
David TrumperDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Linda G GriffithDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-1801-5548
Massachusetts Institute of Technology · USBoston Children's Hospital · USMoscow Institute of Thermal Technology · RUJohns Hopkins University · USYonsei University · KR

Funding

GuMI: New In Vitro Platforms to Parse the Human Gut Epithelial-Microbiome-Immune AxisR01EB021908 · NIBIB · NORTHEASTERN UNIVERSITY · PI CARRIER, REBECCA L, GRIFFITH, LINDA G · 2016 to 2020
$5.2M
NIBIB NIH HHS R01 EB021908
6 · The paper itself

Abstract

Crosstalk of microbes with human gut epithelia and immune cells is crucial for gut health. However, there is no existing system for a long-term co-culture of human innate immune cells with epithelium and oxygen-intolerant commensal microbes, hindering the understanding of microbe-immune interactions in a controlled manner. Here, we establish a gut epithelium-microbe-immune microphysiological system to maintain the long-term continuous co-culture of

Indexed as

Faecalibacterium duncaniaeGuMIGut microbiomehost-microbiome crosstalkorgan-on-a-chip

Identifiers

PMID37886530
PMCPMC10602192
OpenAlexW4387573766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.