Evidence map›Paper›PMID 37886527›Full record

ArticleResearch square2023

A modular microfluidic platform to study how fluid shear stress alters estrogen receptor phenotype in ER

Braulio Andrés Ortega Quesada, Jonathan Cuccia, Rachael Coates, Blake Nassar, Ethan Littlefield, Elizabeth C Martin, Adam T Melvin

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Braulio Andrés Ortega QuesadaCain Department of Chemical Engineering, Louisiana State University, Baton Rouge, LA, 70803.
Jonathan CucciaBiological and Agricultural Engineering, Louisiana State University, Baton Rouge, LA, 70803.
Rachael CoatesBiological and Agricultural Engineering, Louisiana State University, Baton Rouge, LA, 70803.
Blake NassarCain Department of Chemical Engineering, Louisiana State University, Baton Rouge, LA, 70803.
Ethan LittlefieldBiological and Agricultural Engineering, Louisiana State University, Baton Rouge, LA, 70803.
Elizabeth C MartinDepartment Medicine, Section Hematology and Medical Oncology, Tulane University, New Orleans, LA, 70118.
Adam T MelvinCain Department of Chemical Engineering, Louisiana State University, Baton Rouge, LA, 70803.ORCID 0000-0003-0484-5871
Louisiana State University · USTulane University · US

Funding

Maximizing Access to Research Careers at Louisiana State UniversityT34GM136452 · NIGMS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI VICENTE, MARIA DA GRACA HENRIQUES · 2020 to 2024
$1.6M
Evaluating How Fluid Shear Stress Alters Estrogen Receptor Phenotype in Metastatic Breast CancerR03CA262944 · NCI · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI MONROE, WILLIAM T · 2021 to 2022
$140k
NCI NIH HHS R03 CA262944NIGMS NIH HHS T34 GM136452
6 · The paper itself

Abstract

Metastatic breast cancer leads to poor prognoses and worse outcomes in patients due to its invasive behavior and poor response to therapy. It is still unclear what biophysical and biochemical factors drive this more aggressive phenotype in metastatic cancer; however recent studies have suggested that exposure to fluid shear stress in the vasculature could cause this. In this study a modular microfluidic platform capable of mimicking the magnitude of fluid shear stress (FSS) found in human vasculature was designed and fabricated. This device provides a platform to evaluate the effects of FSS on MCF-7 cell line, a receptor positive (ER

Indexed as

endocrine therapyER+ breast cancerfluid shear stressmetastasismicrofluidicssingle cell resolution

Identifiers

PMID37886527
PMCPMC10602101
OpenAlexW4387499184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.