Evidence map›Paper›PMID 37886513›Full record

ArticleResearch square2023

Self-reactive germline-like TCR alpha chains shared between blood and pancreas.

Peter Linsley, Maki Nakayama, Elisa Balmas, Janice Chen, Fariba Pour, Shubham Bansal, Elisavet Serti, Cate Speake, Alberto Pugliese, Karen Cerosaletti

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Peter LinsleyBenaroya Research Institute at Virginia Mason.ORCID 0000-0002-8960-4307
Maki NakayamaBarbara Davis Center for Childhood Diabetes.
Elisa BalmasBenaroya Research Institute.
Janice ChenBenaroya Research Institute.
Fariba PourBenaroya Research Institute.
Shubham BansalBenaroya Research Institute.
Elisavet SertiThe Henry Jackson Foundation.ORCID 0000-0003-4129-0254
Cate SpeakeBenaroya Research Institute.ORCID 0000-0003-1480-4272
Alberto PuglieseCity of Hope.
Karen CerosalettiBenaroya Research Institute, Seattle, WA.ORCID 0000-0002-7403-6239
Diabetes Australia · AUBenaroya Research InstituteJackson Foundation · US

Funding

Immune Tolerance Network UM1 2023 SupplementUM1AI109565 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI Mark S Anderson, Jane Hoyt Buckner · 2014 to 2026
$451.6M
NIAID NIH HHS UM1 AI109565
6 · The paper itself

Abstract

Human islet antigen reactive CD4 + memory T cells (IAR T cells) from peripheral blood have been studied extensively for their role in the pathogenesis of autoimmune type 1 diabetes (T1D). However, IAR T cells are rare, and it remains poorly understood how they affect T1D progression in the pancreas. Using single cell RNA-sequencing coupled with a multiplexed activation induced marker (AIM) enrichment assay, we identified paired TCR alpha/beta (

Identifiers

PMID37886513
PMCPMC10602137
OpenAlexW4387814050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.