Evidence map›Paper›PMID 37886496›Full record

ArticleResearch square2023

Genomic Structural Equation Modeling Reveals Latent Phenotypes in the Human Cortex with Distinct Genetic Architecture.

Rajendra Morey, Yuanchao Zheng, Delin Sun, Melanie Garrett, Marianna Gasperi, Adam Maihofer, C Lexi Baird, Katrina Grasby, Ashley Huggins, Courtney Haswell and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Rajendra MoreyDuke University.
Yuanchao ZhengORCID 0000-0001-7571-3054
Delin SunDuke University Medical Center.ORCID 0000-0003-3283-423X
Melanie Garrett
Marianna Gasperi
Adam MaihoferUCSD.
C Lexi Baird
Katrina GrasbyQIMR Berghofer Medical Research Institute.ORCID 0000-0001-8539-0228
Ashley HugginsDuke University.ORCID 0000-0001-7936-2116
Courtney Haswell
Paul ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California, USA.
Sarah MedlandQIMR Berghofer Medical Research Institute.ORCID 0000-0003-1382-380X
Daniel GustavsonVanderbilt University Medical Center.ORCID 0000-0002-1470-4928
Matthew Panizzon
William Kremen
Caroline Nievergelt
Allison Ashley-KochDuke University.ORCID 0000-0001-5409-9155
Logue Logue

Funding

TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Psychiatric Genomics Consortium for PTSDR01MH106595 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KARESTAN C KOENEN, Caroline M Nievergelt · 2016 to 2026
$8.4M
Trauma and Genomics Modulate Brain Structure across Common Psychiatric DisordersR01MH111671 · NIMH · DUKE UNIVERSITY · PI MARK W LOGUE, RAJENDRA A MOREY · 2017 to 2026
$4.4M
ENIGMA-SD: Understanding Sex Differences in Global Mental Health through ENIGMAR01MH116147 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2021
$2.5M
Neurobiologically-Based Subtyping of Multi-Cohort Samples with MDD and PTSD SymptomsR01MH129832 · NIMH · DUKE UNIVERSITY · PI MOREY, RAJENDRA A, SCHMAAL, LIANNE · 2022 to 2025
$2.3M
White Matter Damage in Subconcussive Blast ExposureR01NS086885 · NINDS · DUKE UNIVERSITY · PI MOREY, RAJENDRA A · 2014 to 2018
$1.7M
FMRI Assessment of Attention and Memory in PTSDK23MH073091 · NIMH · DUKE UNIVERSITY · PI MOREY, RAJENDRA A · 2006 to 2010
$798k
ENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683k
Brain Systems for Fear Generalization and Threat Processing in PTSDI01CX000748 · VA · DURHAM VA MEDICAL CENTER · PI MOREY, RAJENDRA A · 2014 to 2017
–
Chronic pain conditions and internalizing psychopathology, a genetic epidemiology investigation.IK2CX002107 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI Marianna Gasperi · 2021 to 2026
–
Neuroimaging Methods for Diagnosis of Mild Traumatic Brain InjuryI01RX000389 · VA · DURHAM VA MEDICAL CENTER · PI MOREY, RAJENDRA A · 2012 to 2014
–
CSRD VA I01 CX000748CSRD VA IK2 CX002107NIA NIH HHS R56 AG058854NIBIB NIH HHS P41 EB015922NIBIB NIH HHS U54 EB020403NIMH NIH HHS K23 MH073091NIMH NIH HHS R01 MH106595NIMH NIH HHS R01 MH111671NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH129832NINDS NIH HHS R01 NS086885RRD VA I01 RX000389
6 · The paper itself

Abstract

Genetic contributions to human cortical structure manifest pervasive pleiotropy. This pleiotropy may be harnessed to identify unique genetically-informed parcellations of the cortex that are neurobiologically distinct from functional, cytoarchitectural, or other cortical parcellation schemes. We investigated genetic pleiotropy by applying genomic structural equation modeling (SEM) to map the genetic architecture of cortical surface area (SA) and cortical thickness (CT) for the 34 brain regions recently reported in the ENIGMA cortical GWAS. Genomic SEM uses the empirical genetic covariance estimated from GWAS summary statistics with LD score regression (LDSC) to discover factors underlying genetic covariance, which we are denoting

Indexed as

CortexCortical Surface AreaCortical ThicknessGenetically Informed Brain NetworksGenome Wide Association Study (GWAS)Genomic Structural Equation Modeling (gSEM)pleiotropystructural covariance networks (SCN)

Identifiers

PMID37886496
PMCPMC10602057

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.