Evidence map›Paper›PMID 37886490›Full record

ArticleResearch square2023

NCAPH Drives Breast Cancer Progression and Identifies a Gene Signature that Predicts Luminal A Tumor Recurrence.

Marina Mendiburu-Eliçabe, Natalia García-Sancha, Roberto Corchado-Cobos, Angélica Martínez-López, Hang Chang, Jian Hua Mao, Adrián Blanco-Gómez, Ana García-Casas, Andrés Castellanos-Martín, Nélida Salvador and 13 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 4 institutions in 2 countries.

Marina Mendiburu-EliçabeInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, Salamanca, Spain.
Natalia García-SanchaInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, Salamanca, Spain.
Roberto Corchado-CobosInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, Salamanca, Spain.
Angélica Martínez-LópezDepartamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas, Universidad Complutense, Madrid, Spain.
Hang ChangBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Jian Hua MaoBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Adrián Blanco-GómezInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, Salamanca, Spain.
Ana García-CasasDepartamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas, Universidad Complutense, Madrid, Spain.
Andrés Castellanos-MartínInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, Salamanca, Spain.
Nélida SalvadorDepartamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas, Universidad Complutense, Madrid, Spain.
Alejandro Jiménez-NavasInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, Salamanca, Spain.
Manuel Jesús Pérez-BaenaInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, Salamanca, Spain.
Manuel Adolfo Sánchez-MartínDepartamento de Medicina, Universidad de Salamanca, Salamanca, Spain.
María Del Mar Abad-HernándezInstituto de Investigación Biosanitaria de Salamanca (IBSAL), Salamanca, Spain.
Sofía Del CarmenInstituto de Investigación Biosanitaria de Salamanca (IBSAL), Salamanca, Spain.
Juncal Claros-AmpueroInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, Salamanca, Spain.
Juan Jesús Cruz-HernándezInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, Salamanca, Spain.
César Augusto Rodríguez-SánchezInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, Salamanca, Spain.
María Begoña García-CenadorInstituto de Investigación Biosanitaria de Salamanca (IBSAL), Salamanca, Spain.
Francisco Javier García-CriadoInstituto de Investigación Biosanitaria de Salamanca (IBSAL), Salamanca, Spain.
Rodrigo Santamaría VicenteDepartamento de Informática y Automática, Universidad de Salamanca, Salamanca, España.
Sonia Castillo-LluvaDepartamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas, Universidad Complutense, Madrid, Spain.
Jesús Pérez-LosadaInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, Salamanca, Spain.
Universidad de Salamanca · ESInstituto de Investigación Biosanitaria de Granada · ESUniversidad Complutense de Madrid · ESLawrence Berkeley National Laboratory · US

Funding

Molecular and Therapeutic Basis of Morphometric Aberrations in Brain TumorsR01CA184476 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI CHANG, HANG · 2015 to 2019
$2.0M
NCI NIH HHS R01 CA184476
6 · The paper itself

Abstract

Despite their generally favorable prognosis, luminal A tumors paradoxically pose the highest ten-year recurrence risk among breast cancers. From those that relapse, a quarter of them do it within five years after diagnosis. Identifying such patients is crucial, as long-term relapsers could benefit from extended hormone therapy, whereas early relapsers may require aggressive treatment. In this study, we demonstrate that NCAPH plays a role in the pathogenesis of luminal A breast cancer, contributing to its adverse progression

Indexed as

Breast cancerGenetic signatureLASSOLuminal A subtypeNCAPHPrognosisRelapse-free survival

Identifiers

PMID37886490
PMCPMC10602143
OpenAlexW4387673804

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.