Evidence map›Paper›PMID 37886475›Full record

ArticleResearch square2023

An NKG2A biased immune response confers protection for infection, autoimmune disease, and cancer.

James Heath, Daniel Chen, Jingyi Xie, Jongchan Choi, Rachel Ng, Rongyu Zhang, Sarah Li, Rick Edmark, Hong Zheng, Benjamin Solomon and 8 more

Abstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

James HeathInstitute for Systems Biology.ORCID 0000-0001-5356-4385
Daniel ChenInstitute for Systems Biology.ORCID 0000-0001-6660-6257
Jingyi XieInstitute for Systems Biology.
Jongchan ChoiInstitute for Systems Biology.ORCID 0000-0003-0394-9978
Rachel NgInstitute for Systems Biology.ORCID 0000-0003-3692-8524
Rongyu ZhangInstitute for Systems Biology.
Sarah LiInstitute for Systems Biology.
Rick EdmarkInstitute for Systems Biology.
Hong ZhengStanford University.
Benjamin SolomonStanford University.ORCID 0000-0003-1009-7312
Katie CampbellUniversity of California Los Angeles.ORCID 0000-0001-6491-4432
Egmidio MedinaUCLA.ORCID 0000-0002-3284-5329
Antoni RibasUniversity of California, Los Angeles.ORCID 0000-0003-3669-8458
Purvesh KhatriStanford University.ORCID 0000-0002-4143-4708
Lewis LanierUniversity of California San Francisco.ORCID 0000-0003-1308-3952
Philip MeaseSwedish Center for Research and Innovation.
Jason GoldmanSwedish Medical Center.ORCID 0000-0002-3825-6832
Yapeng SuInstitute for Systems Biology.

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
Translational Incubator CoreU19AI109662 · NIAID · STANFORD UNIVERSITY · PI GLENN, JEFFREY S · 2014 to 2019
$28.6M
Spatiotemporal Tumor Analytics for Guiding Sequential Targeted-Inhibitor: Immunotherapy Combinations (ST-Analytics)U54CA274509 · NCI · INSTITUTE FOR SYSTEMS BIOLOGY · PI Rong Fan · 2022 to 2026
$15.6M
Project 3: Modeling and overcoming resistance to melanoma immunotherapyP01CA244118 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MORICEAU, GATIEN P · 2020 to 2024
$12.8M
Stanford Integrated Cardiovascular/Pulmonary Residency Research Training ProgramR38HL143615 · NHLBI · STANFORD UNIVERSITY · PI Michael Peter Fischbein, Marlene Rabinovitch · 2020 to 2026
$2.2M
NCI NIH HHS P01 CA244118NCI NIH HHS P30 CA015704NCI NIH HHS U54 CA274509NHLBI NIH HHS R38 HL143615NIAID NIH HHS U19 AI109662
6 · The paper itself

Abstract

Infection, autoimmunity, and cancer are the principal human health challenges of the 21st century and major contributors to human death and disease. Often regarded as distinct ends of the immunological spectrum, recent studies have hinted there may be more overlap between these diseases than appears. For example, pathogenic inflammation has been demonstrated as conserved between infection and autoimmune settings. T resident memory (T

Identifiers

PMID37886475
PMCPMC10602172

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.