Evidence map›Paper›PMID 37886448›Full record

ArticleResearch square2023

A new Approach to Identify Gene-Environment Interactions and Reveal New Biological Insight in Complex traits.

Xiaofeng Zhu, Yihe Yang, Noah Lorincz-Comi, Gen Li, Amy Bentley, Paul S de Vries, Michael Brown, Alanna C Morrison, Charles Rotimi, W James Gauderman and 2 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Xiaofeng ZhuDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0003-0037-411X
Yihe YangDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0001-6563-3579
Noah Lorincz-ComiDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0002-0517-2499
Gen LiDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
Amy BentleyCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-0827-9101
Paul S de VriesHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Michael BrownHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.ORCID 0000-0001-6381-4296
Charles RotimiCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0001-5759-053X
W James GaudermanBiostatistics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
D C RaoDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Hugues AschardInstitut Pasteur, Université Paris Cité, Department of Computational Biology, F-75015 Paris, France.ORCID 0000-0002-7554-6783
Case Western Reserve University · USNational Institutes of Health · USThe University of Texas Health Science Center at Houston · USCenter for Human Genetics · USInstitut Pasteur · FRUniversity of Southern California · USWashington University in St. Louis · US

Funding

A Multi-Ancestry Study of Gene-Lifestyle Interactions and Multi-Omics in Cardiometabolic TraitsR01HL156991 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 2021 to 2024
$8.8M
Statistical Analysis of Large Genomic Data SetsR01HG011052 · NHGRI · CASE WESTERN RESERVE UNIVERSITY · PI XIAOFENG ZHU · 2020 to 2026
$3.3M
Genetic epidemiology of complex diseasesZ01HG200362 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ROTIMI, CHARLES · 2008 to 2008
$1.7M
Intramural NIH HHS Z01 HG200362NHGRI NIH HHS R01 HG011052NHLBI NIH HHS R01 HL156991
6 · The paper itself

Abstract

There is a long-standing debate about the magnitude of the contribution of gene-environment interactions to phenotypic variations of complex traits owing to the low statistical power and few reported interactions to date. To address this issue, the CHARGE Gene-Lifestyle Interactions Working Group has been spearheading efforts to investigate

Identifiers

PMID37886448
PMCPMC10602131
OpenAlexW4387327762

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.