Evidence map›Paper›PMID 37886436›Full record

ArticleResearch square2023

Multi-ancestry Polygenic Mechanisms of Type 2 Diabetes Elucidate Disease Processes and Clinical Heterogeneity.

Kirk Smith, Aaron J Deutsch, Carolyn McGrail, Hyunkyung Kim, Sarah Hsu, Ravi Mandla, Philip H Schroeder, Kenneth E Westerman, Lukasz Szczerbinski, Timothy D Majarian and 8 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 3 countries.

Kirk SmithDiabetes Unit, Massachusetts General Hospital, Boston, MA, USA.
Aaron J DeutschDiabetes Unit, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-6750-5335
Carolyn McGrailDepartment of Pediatrics, University of California San Diego, San Diego, CA, USA.
Hyunkyung KimDiabetes Unit, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-7964-3073
Sarah HsuPrograms in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ravi MandlaDiabetes Unit, Massachusetts General Hospital, Boston, MA, USA.
Philip H SchroederDiabetes Unit, Massachusetts General Hospital, Boston, MA, USA.
Kenneth E WestermanPrograms in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Lukasz SzczerbinskiDiabetes Unit, Massachusetts General Hospital, Boston, MA, USA.
Timothy D MajarianPrograms in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Varinderpal KaurDiabetes Unit, Massachusetts General Hospital, Boston, MA, USA.
Alice WilliamsonPrecision Healthcare University Research Institute, Queen Mary University of London, London, UK.
Melina ClaussnitzerPrograms in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jose C FlorezDiabetes Unit, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-1730-9325
Alisa K ManningPrograms in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Josep M MercaderPrograms in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-8494-3660
Kyle J GaultonDepartment of Pediatrics, University of California San Diego, San Diego, CA, USA.
Miriam S UdlerDiabetes Unit, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-3824-9162
Broad Institute · USQueen Mary University of London · GBUniversity of California San Diego · US

Funding

TRAINING PROGRAM IN ENDOCRINOLOGY AND DIABETEST32DK007028 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Karen K Miller · 1986 to 2026
$18.5M
Bridging the gap between type 2 diabetes GWAS and therapeutic targetsUM1DK126185 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CLAUSSNITZER, MELINA C, GLOYN, ANNA LOUISE · 2020 to 2024
$9.5M
Development of Polygenic Risk Scores for Diabetes and Complications across the Life-Span in Populations of Multiple AncestriesU01HG011723 · NHGRI · BROAD INSTITUTE, INC. · PI Alisa Knodle Manning, Josep Maria Mercader · 2021 to 2026
$5.7M
Clinical Implications of Genetically Defined Diabetes Subtypes and Application to Electronic Health Medical Record SystemsK23DK114551 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI UDLER, MIRIAM SARGON · 2017 to 2021
$1000k
Improved detection of gene-diet interactions via longitudinal data, metabolomic proxies, and polygenic scoresK01DK133637 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Kenneth E Westerman · 2022 to 2026
$749k
Extension of Type 2 Diabetes Genetic Clustering to Populations of non-European AncestryR03DK131249 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI UDLER, MIRIAM SARGON · 2022 to 2023
$252k
Analysis of Type 1 Diabetes Polygenic Scores in Atypical Forms of DiabetesF32DK137487 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI DEUTSCH, AARON JONATHAN · 2023 to 2023
$82k
NHGRI NIH HHS U01 HG011723NIDDK NIH HHS F32 DK137487NIDDK NIH HHS K01 DK133637NIDDK NIH HHS K23 DK114551NIDDK NIH HHS L30 DK106874NIDDK NIH HHS R03 DK131249NIDDK NIH HHS T32 DK007028NIDDK NIH HHS UM1 DK126185
6 · The paper itself

Abstract

We identified genetic subtypes of type 2 diabetes (T2D) by analyzing genetic data from diverse groups, including non-European populations. We implemented soft clustering with 650 T2D-associated genetic variants, capturing known and novel T2D subtypes with distinct cardiometabolic trait associations. The twelve genetic clusters were distinctively enriched for single-cell regulatory regions. Polygenic scores derived from the clusters differed in distribution between ancestry groups, including a significantly higher proportion of lipodystrophy-related polygenic risk in East Asian ancestry. T2D risk was equivalent at a BMI of 30 kg/m

Identifiers

PMID37886436
PMCPMC10602111
OpenAlexW4387458083

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.