Evidence map›Paper›PMID 37886403›Full record

Article3D printing and additive manufacturing2023

Three-Dimensional Printed Hydroxyapatite Bone Substitutes Designed by a Novel Periodic Minimal Surface Algorithm Are Highly Osteoconductive.

Ekaterina Maevskaia, Nupur Khera, Chafik Ghayor, Indranil Bhattacharya, Julien Guerrero, Flora Nicholls, Christian Waldvogel, Ralph Bärtschi, Lea Fritschi, Dániel Salamon and 5 more

Abstract read
In one paragraph

Article in 3D printing and additive manufacturing, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ekaterina MaevskaiaOral Biotechnology & Bioengineering, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.
Nupur KheraOral Biotechnology & Bioengineering, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.
Chafik GhayorOral Biotechnology & Bioengineering, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.
Indranil BhattacharyaOral Biotechnology & Bioengineering, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.
Julien GuerreroOral Biotechnology & Bioengineering, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.
Flora NichollsCentral Biological Laboratory, University Hospital Zurich, Zurich, Switzerland.
Christian WaldvogelSpherene, Zurich, Switzerland.
Ralph BärtschiSpherene, Zurich, Switzerland.
Lea FritschiSpherene, Zurich, Switzerland.
Dániel SalamonSpherene, Zurich, Switzerland.
Mutlu ÖzcanCenter of Dental Medicine, Division of Dental Biomaterials, Clinic for Reconstructive Dentistry, University of Zurich, Zurich, Switzerland.
Patrick MalgaroliInstitute for Medical Engineering and Medical Informatics IM2, School of Life Sciences, University of Applied Sciences Northwestern Switzerland, FHNW, Muttenz, Switzerland.
Daniel SeilerInstitute for Medical Engineering and Medical Informatics IM2, School of Life Sciences, University of Applied Sciences Northwestern Switzerland, FHNW, Muttenz, Switzerland.
Michael de WildInstitute for Medical Engineering and Medical Informatics IM2, School of Life Sciences, University of Applied Sciences Northwestern Switzerland, FHNW, Muttenz, Switzerland.
Franz E WeberOral Biotechnology & Bioengineering, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0003-1670-2296

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autologous bone remains the gold standard bone substitute in clinical practice. Therefore, the microarchitecture of newly developed synthetic bone substitutes, which reflects the spatial distribution of materials in the scaffold, aims to recapitulate the natural bone microarchitecture. However, the natural bone microarchitecture is optimized to obtain a mechanically stable, lightweight structure adapted to the biomechanical loading situation. In the context of synthetic bone substitutes, the application of a Triply Periodic Minimum Surface (TPMS) algorithm can yield stable lightweight microarchitectures that, despite their demanding architectural complexity, can be produced by additive manufacturing. In this study, we applied the TPMS derivative Adaptive Density Minimal Surfaces (ADMS) algorithm to produce scaffolds from hydroxyapatite (HA) using a lithography-based layer-by-layer methodology and compared them with an established highly osteoconductive lattice microarchitecture. We characterized them for compression strength, osteoconductivity, and bone regeneration. The

Indexed as

3D printingadaptive density minimal surfacesadditive manufacturingADMSbone substituteceramicshydroxyapatitemicroarchitectureosteoconductiontitaniumTPMStriply periodic minimal surface

Identifiers

PMID37886403
PMCPMC10599419

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.