ArticleBioactive materials2024
Full-thickness osteochondral defect repair using a biodegradable bilayered scaffold of porous zinc and chondroitin sulfate hydrogel.
Article in Bioactive materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- AI-powered the toughest biohydrogels.Bioactive materials · 2026Article
- A biomimetic 3D printed gradient tri-layered scaffold stimulating osteochondral differentiation of mesenchymal stem cells for mandibular condyle regeneration.BMC oral health · 2026Article
- Application of hydrogel technologies in the treatment of musculoskeletal disorders.Chinese medical journal · 2026Review
- Application and prospect of zinc oxide nanoparticle-enhanced biomimetic hydrogels in articular cartilage repair.Biochemistry and biophysics reports · 2026Review
- Topographical design principles for osteochondral tissue engineering.Bioactive materials · 2026Review
- Natural Biomaterials for Osteochondral Repair: From Source to Strategy.Advanced healthcare materials · 2026Review
- Biophysical signal-driven scaffold design for stem cell-guided osteochondral regeneration.Bioactive materials · 2026Review
- Precisely regulated physically-crosslinked carriers enable synergetic release of bioactive factors for MSC-mediated cartilage regeneration.Bioactive materials · 2026Article
- Glycosaminoglycans in tissue regeneration: Insights into glycobiology and their biomedical application.Bioactive materials · 2026Review
- Exosome-mediated Piezo1 activation in 3D-printed titanium scaffolds promotes repair of femoral head osteonecrosis.Journal of nanobiotechnology · 2026Article
- Hydrogels for Bone Repair: Construction Strategies and Applications.Smart medicine · 2026Review
- Functionalized hydrogels of CeOMaterials today. Bio · 2026Article
- Design and Fabrication of Biomimetic Gradient Bone Tissue Engineering Scaffolds: Evolution from Single-Gradient to Multi-Gradient.Gels (Basel, Switzerland) · 2026Review
- Integrated 3D printing of topologically hierarchical mechanical hydrogel for accelerating osteochondral regeneration.Bioactive materials · 2026Article
- Hydrogels for Osteochondral Interface Regeneration: Biomaterial Types, Processes, and Animal Models.Gels (Basel, Switzerland) · 2025Review
- Evaluation of cartilage regeneration using a hybrid bilayer scaffold based on omentum: evidence of limited efficacy.Journal of orthopaedic surgery and research · 2025Article
- 3D-printed advanced scaffold armed with exosomes derived from human skeletal stem cell identified by single-cell RNA sequencing enhances osteochondral regeneration.Bioactive materials · 2025Article
- Evaluation of the efficacy of a double-layered and single-layered synthetic scaffold for the treatment of knee osteochondral defects - an experimental study.Journal of orthopaedic surgery and research · 2025Article
- Continuous mechanical-gradient hydrogel with on-demand distributed MnBioactive materials · 2025Article
- Migrasomes: a promising extracellular vesicle-like novel organelle for bone regeneration.Regenerative medicine · 2025Review
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10 authors.
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Abstract
The regeneration of osteochondral tissue necessitates the re-establishment of a gradient owing to the unique characteristics and healing potential of the chondral and osseous phases. As the self-healing capacity of hyaline cartilage is limited, timely mechanical support during neo-cartilage formation is crucial to achieving optimal repair efficacy. In this study, we devised a biodegradable bilayered scaffold, comprising chondroitin sulfate (CS) hydrogel to regenerate chondral tissue and a porous pure zinc (Zn) scaffold for regeneration of the underlying bone as mechanical support for the cartilage layer. The photocured CS hydrogel possessed a compressive strength of 82 kPa, while the porous pure Zn scaffold exhibited a yield strength of 11 MPa and a stiffness of 0.8 GPa. Such mechanical properties are similar to values reported for cancellous bone. In vitro biological experiments demonstrated that the bilayered scaffold displayed favorable cytocompatibility and promoted chondrogenic and osteogenic differentiation of bone marrow stem cells. Upon implantation, the scaffold facilitated the simultaneous regeneration of bone and cartilage tissue in a porcine model, resulting in (i) a smoother cartilage surface, (ii) more hyaline-like cartilage, and (iii) a superior integration into the adjacent host tissue. Our bilayered scaffold exhibits significant potential for clinical application in osteochondral regeneration.
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