Evidence map›Paper›PMID 37885598›Full record

ArticlePaediatrics & child health2023

Short duration of parenteral antibiotics in infants with urinary tract infections.

Nikita Menon, Anne Mutinta Deasy, Kellan Woo, Jalal Tarabishi, Eugene Yu-Hin Chan, Kristopher Kang, Matthew Carwana, Nassr Nama

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Paediatrics & child health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Nikita MenonVancouver-Fraser Medical Program, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia.ORCID https://orcid.org/0000-0002-9469-1492
Anne Mutinta DeasyDepartment of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, British Columbia.
Kellan WooVancouver-Fraser Medical Program, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia.
Jalal TarabishiDepartment of Biological Sciences, Faculty of Science, University of Alberta, Edmonton, Alberta.
Eugene Yu-Hin ChanPaediatric Nephrology Centre, Hong Kong Children's Hospital, Hong Kong, Hong Kong.
Kristopher KangDepartment of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, British Columbia.ORCID https://orcid.org/0000-0002-5144-3800
Matthew CarwanaDepartment of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, British Columbia.
Nassr NamaBC Children's Hospital Research Institute, Evidence to Innovation, Vancouver, British Columbia.ORCID https://orcid.org/0000-0002-0199-3599
University of British Columbia · CADuchess of Kent Children's Hospital · CNSeattle Children's Hospital · USUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Current guidelines by the Canadian Paediatric Society on treating urinary tract infections (UTIs) exclude infants ≤ 60 days old. There is considerable practice variability in this age group, especially around the optimal duration of parenteral antibiotics. The study aimed to assess local practice patterns, and the safety of a short course (≤3 days) of parenteral antibiotics in young infants. Methods: In this retrospective cohort study, 95 infants (≤60 days) with confirmed UTIs were identified at British Columbia Children's Hospital. Patients receiving short (≤3 days) and long (>3 days) duration of parenteral antibiotics were compared. Outcomes of interest included urinary tract infection recurrence within 30 days, hospital length of stay (LOS), representation, and readmission. Results: Twenty infants (21%) received a short course of parenteral antibiotics. These infants were older (median 47 days versus 28 days) and non-bacteremic. Urinary tract infection recurrence was identified in 8 patients (8%), of which 7 were treated with a long duration (P = 1.0). Patients treated with a short duration had a significantly shorter LOS, with a mean difference of 4.21 days [95% CI: 3.37 to 5.05] (P < 0.001). All five (5%) bacteremic patients were treated exclusively with parenteral antibiotics. Conclusions: In a Canadian setting, a short course of parenteral antibiotics is safe in young, non-bacteremic infants with UTIs. Despite substantial evidence, local practice patterns suggest a tendency towards prescription of long courses, providing an opportunity for quality improvement.

Indexed as

Anti-bacterial agentsInfant healthUrinary tract infections

Identifiers

PMID37885598
PMCPMC10599490
OpenAlexW4380434121

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.