SynthesisFrontiers in neurology2023
Assessing the diagnostic accuracy of CT perfusion: a systematic review.
Synthesis in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Rethinking reperfusion metrics in endovascular stroke therapy: the limitations of mTICI and a path forward toward more meaningful outcomes.Neuroradiology · 2026Article
- Preoperative volume of mildly delayed time predicts 24-hour complete reperfusion after successful mechanical thrombectomy.BMC neurology · 2026Article
- Development and Validation of a Harmonization Pipeline for Multi-Site Computed Tomography Perfusion Cerebral Blood Flow Maps-An Analysis of the AcT Trial.Clinical neuroradiology · 2026Article
- Model based noise correction enhances the accuracy of pancreatic CT perfusion blood flow measurements.Scientific reports · 2025Article
- Accuracy of computed tomography perfusion-defined ischemic core and follow-up infarction after basilar artery thrombectomy.Frontiers in neurology · 2025Article
- Utility of automated CT perfusion software in acute ischemic stroke with large and medium vessel occlusion.Annals of clinical and translational neurology · 2024Article
- Deep Learning-Based Prediction of Final Infarct Core from CT Perfusion Data: A Comparison to the Clinical Standard.Stroke (Hoboken, N.J.) · 2024Article
- The novel imaging methods in diagnosis and assessment of cerebrovascular diseases: an overview.Frontiers in medicine · 2024Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and purpose: Computed tomography perfusion (CTP) has successfully extended the time window for reperfusion therapies in ischemic stroke. However, the published perfusion parameters and thresholds vary between studies. Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses of Diagnostic Test Accuracy Studies (PRISMA-DTA) guidelines, we conducted a systematic review to investigate the accuracy of parameters and thresholds for identifying core and penumbra in adult stroke patients. Methods: We searched Medline, Embase, the Cochrane Library, and reference lists of manuscripts up to April 2022 using the following terms "computed tomography perfusion," "stroke," "infarct," and "penumbra." Studies were included if they reported perfusion thresholds and undertook co-registration of CTP to reference standards. The quality of studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool and Standards for Reporting of Diagnostic Accuracy (STARD) guidelines. Results: A total of 24 studies were included. A meta-analysis could not be performed due to insufficient data and significant heterogeneity in the study design. When reported, the mean age was 70.2 years (SD+/-3.69), and the median NIHSS on admission was 15 (IQR 13-17). The perfusion parameter identified for the core was relative cerebral blood flow (rCBF), with a median threshold of <30% (IQR 30, 40%). However, later studies reported lower thresholds in the early time window with rapid reperfusion (median 25%, IQR 20, 30%). A total of 15 studies defined a single threshold for all brain regions irrespective of collaterals and the gray and white matter. Conclusion: A single threshold and parameter may not always accurately differentiate penumbra from core and oligemia. Further refinement of parameters is needed in the current era of reperfusion therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.