ArticleEuropean stroke journal2024
First pass effect as an independent predictor of functional outcomes in medium vessel occlusions: An analysis of an international multicenter study.
Abstract readMulticenter Study
In one paragraph
Article in European stroke journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Hyperdense sign as a predictor for successful recanalization and clinical outcome in acute ischemic stroke: A systematic review and meta-analysis.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Pooled it
- Distal Placement of Guide Catheter Improves Efficacy of Endovascular Thrombectomy in Large Vessel Occlusion Stroke: a Systematic Review and Meta-analysis.Clinical neuroradiology · 2026Pooled it
- Efficacy and safety of intravenous tenecteplase compared to alteplase before mechanical thrombectomy in acute ischemic stroke: a meta-analysis.Journal of neurology · 2024Pooled it
- Intra-Arterial Thrombolytic vs. Mechanical Thrombectomy in Distal Medium Middle Cerebral Artery Acute Ischemic Stroke: A Preliminary Multinational Multicenter Propensity Score-Matched Study.Clinical neuroradiology · 2026Observational
- Intravenous Thrombolysis in Distal Medium Middle Cerebral Artery Occlusion Patients with Unsuccessful Mechanical Reperfusion.Clinical neuroradiology · 2026Article
- Sex-Related Differences in Outcomes of Endovascular Treatment of Distal Medium Vessel Occlusion Strokes.Clinical neuroradiology · 2026Article
- First-line Aspiration Thrombectomy with the RED43 Catheter for Acute Ischemic Stroke due to Medium or Distal Vessel Occlusion.Clinical neuroradiology · 2026Article
- Efficacy of the Dual Stent Retriever Technique for Branching-Site Occlusions in Mechanical Thrombectomy.Journal of neuroendovascular therapy · 2026Article
- Clinical outcomes of patients with unsuccessful mechanical thrombectomy versus best medical management of medium vessel occlusion stroke in the middle cerebral artery territory.Journal of neurointerventional surgery · 2025Article
- Hypoperfusion intensity ratio is associated with follow-up infarct volume in medium vessel occlusions: A multicenter multinational study.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Dual-Energy CT-Based Assessment of Thrombotic Heterogeneity for Predicting Stroke Source and Response to Machine Thrombectomy: A Step Toward Visualization Thrombus Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Baseline predictors of poor clinical outcome despite recanalization of distal middle cerebral artery occlusions.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Efficacy and safety of mechanical thrombectomy in distal medium middle cerebral artery occlusion ischemic stroke patients on low-dose aspirin.International journal of stroke : official journal of the International Stroke Society · 2025Article
- Observational
- Predictive value of follow-up infarct volume on functional outcomes in middle cerebral artery M2 segment vessel occlusion stroke treated with mechanical thrombectomy.European stroke journal · 2025Article
- Endovascular therapy versus medical management in isolated anterior cerebral artery acute ischemic stroke: a multinational multicenter propensity score-weighted study.Journal of neurointerventional surgery · 2025Article
- Endovascular therapy versus medical management in isolated posterior cerebral artery acute ischemic stroke: A multinational multicenter propensity score-weighted study.European stroke journal · 2025Article
- A multicenter, propensity score-matched analysis of functional outcomes and recanalization success with or without Trevo for Medium and distal vessel occlusion.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Association of Pretreatment Perfusion Imaging Parameters with 90-Day Excellent Functional Outcomes in Anterior Circulation Distal Medium Vessel Occlusion Stroke.AJNR. American journal of neuroradiology · 2025Article
- Atrial fibrillation is associated with lower likelihood of first-pass effect in thrombectomy for medium vessel occlusion acute ischemic strokes.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
87 authors.
Răzvan Alexandru RaduDepartment of Neuroradiology, Gui de Chauliac Hospital, Montpellier University Medical Center, Montpellier, France.ORCID 0000-0001-6375-8466
Vincent CostalatDepartment of Neuroradiology, Gui de Chauliac Hospital, Montpellier University Medical Center, Montpellier, France.
Robert FahedDivision of Neurology, Department of Medicine, The Ottawa Hospital, Ottawa Hospital Research Institute and University of Ottawa, Ottawa, ON, Canada.ORCID 0000-0002-1887-5097
Sherief GhozyDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
James E SieglerCooper Neurological Institute, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, NJ, USA.
Hamza ShaikhCooper Neurological Institute, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, NJ, USA.
Jane KhalifeCooper Neurological Institute, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, NJ, USA.
Mohamad AbdalkaderDepartments of Radiology & Neurology, Boston Medical Center, Boston, MA, USA.
Piers KleinDepartments of Radiology & Neurology, Boston Medical Center, Boston, MA, USA.ORCID 0000-0001-7468-137X
Thanh N NguyenDepartments of Radiology & Neurology, Boston Medical Center, Boston, MA, USA.ORCID 0000-0002-2810-1685
Jeremy J HeitDepartment of Interventional Neuroradiology, Stanford Medical Center, Palo Alto, CA, USA.ORCID 0000-0003-1055-8000
Ahmad SweidDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Kareem El NaamaniDepartment of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA.
Robert W RegenhardtNeuroendovascular Program, Massachusetts General Hospital, Harvard University, Boston, MA, USA.
Jose Danilo Bengzon DiestroNeurovascular Centre, Departments of Medical Imaging and Neurosurgery, St. Michael's Hospital, Toronto, ON, Canada.
Nicole M CancelliereNeurovascular Centre, Departments of Medical Imaging and Neurosurgery, St. Michael's Hospital, Toronto, ON, Canada.
Abdelaziz AmllayDepartment of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA.
Lukas MeyerDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Anne DusartDepartment of Neurology, Hôpital Civil Marie Curie, Charleroi, Belgium.
Flavio BellanteDepartment of Neurology, Hôpital Civil Marie Curie, Charleroi, Belgium.ORCID 0000-0002-8718-9250
Géraud ForestierUniversity Hospital of Limoges, Neuroradiology Department, Dupuytren, Université de Limoges, XLIM CNRS, UMR 7252, Limoges, France.ORCID 0000-0003-4797-9693
Aymeric RouchaudUniversity Hospital of Limoges, Neuroradiology Department, Dupuytren, Université de Limoges, XLIM CNRS, UMR 7252, Limoges, France.
Suzana SalemeUniversity Hospital of Limoges, Neuroradiology Department, Dupuytren, Université de Limoges, XLIM CNRS, UMR 7252, Limoges, France.
Charbel MounayerUniversity Hospital of Limoges, Neuroradiology Department, Dupuytren, Université de Limoges, XLIM CNRS, UMR 7252, Limoges, France.
Jens FiehlerDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Anna Luisa KühnDepartment of Radiology, University of Massachusetts Memorial Hospital, Worcester, MA, USA.ORCID 0000-0001-9512-9461
Ajit S PuriDepartment of Radiology, University of Massachusetts Memorial Hospital, Worcester, MA, USA.
Christian DyzmannDepartment of Diagnostic and Interventional Radiology and Neuroradiology, Sana Klinik Lübeck, Lübeck, Germany.
Peter T KanDepartment of Neurosurgery, University of Texas Medical Branch, Galveston, Texas, USA.
Marco ColasurdoDepartment of Neurosurgery, University of Texas Medical Branch, Galveston, Texas, USA.
Gaultier MarnatInterventional Neuroradiology Department, Bordeaux University Hospital, Bordeaux, France.ORCID 0000-0002-7611-7753
Jérôme BergeInterventional Neuroradiology Department, Bordeaux University Hospital, Bordeaux, France.
Xavier BarreauInterventional Neuroradiology Department, Bordeaux University Hospital, Bordeaux, France.
Igor SibonNeurology Department, Bordeaux University Hospital, Bordeaux, France.
Simona NedelcuDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Nils HenningerDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Maéva KyhengDepartment of Biostatistics, CHU Lille, Lille, France.
Thomas R MarottaNeurovascular Centre, Departments of Medical Imaging and Neurosurgery, St. Michael's Hospital, Toronto, ON, Canada.
Christopher J StapletonNeuroendovascular Program, Massachusetts General Hospital, Harvard University, Boston, MA, USA.
James D RabinovNeuroendovascular Program, Massachusetts General Hospital, Harvard University, Boston, MA, USA.
Takahiro OtaDepartment of Neurosurgery, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan.ORCID 0000-0002-5108-6719
Shogo DofukuDepartment of Neurosurgery, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan.ORCID 0000-0002-3064-8858
Leonard Ll YeoDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID 0000-0002-4249-0402
Benjamin Yq TanDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Juan Carlos Martinez-GutierrezDepartment of Neurology, UTHealth McGovern Medical School, Houston, TX, USA.
Sergio Salazar-MarioniDepartment of Neurology, UTHealth McGovern Medical School, Houston, TX, USA.ORCID 0000-0002-2722-7542
Sunil ShethDepartment of Neurology, UTHealth McGovern Medical School, Houston, TX, USA.
Leonardo RenieriInterventistica Neurovascolare, Ospedale Careggi di Firenze, Florence, Italy.
Carolina CapirossiInterventistica Neurovascolare, Ospedale Careggi di Firenze, Florence, Italy.
Ashkan MowlaDivision of Stroke and Endovascular Neurosurgery, Department of Neurological Surgery, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA, USA.
Stavropoula I TjoumakarisDepartment of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA.
Pascal JabbourDepartment of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0002-8965-2413
Priyank KhandelwalDepartment of Endovascular Neurosurgery and Neuroradiology, NJMS, Newark, NJ, USA.
Arundhati BiswasDepartment of Neurosurgery, Westchester Medical Center at New York Medical College, Valhalla, NY, USA.
Frédéric ClarençonDepartment of Neuroradiology, Pitié-Salpêtrière Hospital. Paris. France; GRC BioFast, Sorbonne University, Paris VI, France.
Mahmoud ElhoranyDepartment of Neuroradiology, Pitié-Salpêtrière Hospital. Paris. France; GRC BioFast, Sorbonne University, Paris VI, France.
Kevin PrematDepartment of Neuroradiology, Pitié-Salpêtrière Hospital. Paris. France; GRC BioFast, Sorbonne University, Paris VI, France.
Iacopo ValenteUOSA Neuroradiologia Interventistica, Fondazione Policlinico Universitario A.Gemelli IRCCS, Roma, Italy.
Alessandro PedicelliUOSA Neuroradiologia Interventistica, Fondazione Policlinico Universitario A.Gemelli IRCCS, Roma, Italy.
João Pedro FilipeDepartment of Diagnostic and Interventional Neuroradiology, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Ricardo VarelaDepartment of Neurology, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Miguel Quintero-ConsuegraDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Nestor R GonzalezDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0002-8277-6317
Markus A MöhlenbruchSektion Vaskuläre und Interventionelle Neuroradiologie, Universitätsklinikum Heidelberg, Heidelberg, Germany.ORCID 0000-0002-5075-704X
Jessica JesserSektion Vaskuläre und Interventionelle Neuroradiologie, Universitätsklinikum Heidelberg, Heidelberg, Germany.ORCID 0000-0002-1236-8828
Illario TancrediDepartment of Radiology, Hôpital Civil Marie Curie, Charleroi, Belgium.
Adrien Ter SchiphorstDepartment of Neurology, Gui de Chauliac Hospital, Montpellier University Medical Center, Montpellier, France.
Vivek YedavalliDivision of Neuroradiology, Department of Radiology, Johns Hopkins Medical Center, Baltimore, Maryland, USA.
Pablo HarkerDepartment of Neurology, University of Cincinnati Medical Center, Cincinnati, OH, USA.
Lina M ChervakDepartment of Neurology, University of Cincinnati Medical Center, Cincinnati, OH, USA.
Yasmin AzizDepartment of Neurology, University of Cincinnati Medical Center, Cincinnati, OH, USA.ORCID 0000-0002-3515-4005
Benjamin GoryDepartment of Interventional Neuroradiology, Nancy University Hospital, Nancy, France.
Christian Paul StrackeDepartment of Radiology, Interventional Neuroradiology Section, University Medical Center Münster, Münster, Germany.
Constantin HeckerDepartments of Neurology & Neurosurgery, Christian Doppler Clinic, Paracelsus Medical University, Salzburg, Austria.
Monika Killer-OberpfalzerDepartments of Neurology & Neurosurgery, Christian Doppler Clinic, Paracelsus Medical University, Salzburg, Austria.
Christoph J GriessenauerDepartments of Neurology & Neurosurgery, Christian Doppler Clinic, Paracelsus Medical University, Salzburg, Austria.
Ajith J ThomasCooper Neurological Institute, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, NJ, USA.
Cheng-Yang HsiehNeurology Department, Sin-Lau Hospital, Tainan.
David S LiebeskindUCLA Stroke Center and Department of Neurology Department, UCLA, Los Angeles, CA, USA.
Andrea M AlexandreUOSA Neuroradiologia Interventistica, Fondazione Policlinico Universitario A.Gemelli IRCCS, Roma, Italy.
Tobias D FaizyDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-1631-2020
Charlotte WeylandSektion Vaskuläre und Interventionelle Neuroradiologie, Universitätsklinikum Heidelberg, Heidelberg, Germany.
Aman B PatelNeuroendovascular Program, Massachusetts General Hospital, Harvard University, Boston, MA, USA.
Vitor Mendes PereiraNeurovascular Centre, Departments of Medical Imaging and Neurosurgery, St. Michael's Hospital, Toronto, ON, Canada.
Boris LubiczDepartment of Interventional Neuroradiology, Erasme University Hospital, Brussels, Belgium.
Adam A DmytriwNeuroendovascular Program, Massachusetts General Hospital, Harvard University, Boston, MA, USA.
Adrien GuenegoDepartment of Interventional Neuroradiology, Erasme University Hospital, Brussels, Belgium.
Funding
Role of Sarm1 in TBI-accentuated C9orf72 Frontotemporal DementiaR21NS131756 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HENNINGER, NILS · 2023 to 2024
$461kNINDS NIH HHS R21 NS131756
Abstract
introductionFirst pass effect (FPE), achievement of complete recanalization (mTICI 2c/3) with a single pass, is a significant predictor of favorable outcomes for endovascular treatment (EVT) in large vessel occlusion stroke (LVO). However, data concerning the impact on functional outcomes and predictors of FPE in medium vessel occlusions (MeVO) are scarce. PATIENTS AND
methodsWe conducted an international retrospective study on MeVO cases. Multivariable logistic modeling was used to establish independent predictors of FPE. Clinical and safety outcomes were compared between the two study groups (FPE vs non-FPE) using logistic regression models. Good outcome was defined as modified Rankin Scale 0-2 at 3 months.
resultsEight hundred thirty-six patients with a final mTICI ⩾ 2b were included in this analysis. FPE was observed in 302 patients (36.1%). In multivariable analysis, hypertension (aOR 1.55, 95% CI 1.10-2.20) and lower baseline NIHSS score (aOR 0.95, 95% CI 0.93-0.97) were independently associated with an FPE. Good outcomes were more common in the FPE versus non-FPE group (72.8% vs 52.8%), and FPE was independently associated with favorable outcome (aOR 2.20, 95% CI 1.59-3.05). 90-day mortality and intracranial hemorrhage (ICH) were significantly lower in the FPE group, 0.43 (95% CI, 0.25-0.72) and 0.55 (95% CI, 0.39-0.77), respectively.
conclusionOver 2/3 of patients with MeVOs and FPE in our cohort had a favorable outcome at 90 days. FPE is independently associated with favorable outcomes, it may reduce the risk of any intracranial hemorrhage, and 3-month mortality.
Indexed as
Brain IschemiaStrokeHumansIntracranial HemorrhagesRetrospective StudiesThrombectomyTreatment OutcomeMeVOoutcomes researchreperfusionStrokethrombectomy
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