Evidence map›Paper›PMID 37885155›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2024

Association between placental oxygen transport and fetal brain cortical development: a study in monochorionic diamniotic twins.

Esra Abaci Turk, Hyuk Jin Yun, Henry A Feldman, Joo Young Lee, Hyun Ju Lee, Carolina Bibbo, Cindy Zhou, Rubii Tamen, Patricia Ellen Grant, Kiho Im

Registry-linked trialOpen access · bronzeAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06290232 (Fetoscopic Laser Photocoagulation in Management of Vasa Previa - FLUMEN Study), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06290232 nawithdrawnnot on this mapstarted 2026, after this paper: background citation

Fetoscopic Laser Photocoagulation in Management of Vasa Previa - FLUMEN Study

TypeinterventionalSponsorBoston Children's HospitalRan2026 to 2028Enrolled0ConditionsVasa Previa, Pregnancy Complications, Maternal, ProcedureArmsFetoscopic Laser Photocoagulation
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Esra Abaci TurkDepartment of Pediatrics, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, United States.
Hyuk Jin YunDepartment of Pediatrics, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, United States.
Henry A FeldmanDepartment of Pediatrics, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, United States.
Joo Young LeeDepartment of Pediatrics, Hanyang University College of Medicine, 222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, South Korea.
Hyun Ju LeeDepartment of Pediatrics, Hanyang University College of Medicine, 222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, South Korea.
Carolina BibboDepartment of Obstetrics and Gynecology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, United States.
Cindy ZhouDivision of Newborn Medicine, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115, United States.
Rubii TamenDivision of Newborn Medicine, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115, United States.
Patricia Ellen GrantDepartment of Pediatrics, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, United States.
Kiho ImDepartment of Pediatrics, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, United States.
Boston Children's Hospital · USHanyang University · KRBrigham and Women's Hospital · US

Funding

Novel MRI Assessment of Placental Structure and Function Throughout PregnancyR01HD100009 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI ADALSTEINSSON, ELFAR, GRANT, PATRICIA ELLEN · 2019 to 2023
$3.6M
Genetic and Hemodynamic Effects on Prenatal Cortical Development in Congenital Heart DiseaseR01NS114087 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI IM, KIHO · 2020 to 2024
$2.8M
Fetal MRI: robust self-driving brain acquisition and body movement quantificationR01EB032708 · NIBIB · BOSTON CHILDREN'S HOSPITAL · PI ADALSTEINSSON, ELFAR, GRANT, PATRICIA ELLEN · 2022 to 2025
$2.8M
Effect of placental oxygen transport on the fetal cortical growth and foldingR21HD094130 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI IM, KIHO · 2018 to 2019
$474k
NIBIB NIH HHS R01 EB032708NICHD NIH HHS R01 HD100009NICHD NIH HHS R21 HD094130NINDS NIH HHS R01 NS114087
6 · The paper itself

Abstract

Normal cortical growth and the resulting folding patterns are crucial for normal brain function. Although cortical development is largely influenced by genetic factors, environmental factors in fetal life can modify the gene expression associated with brain development. As the placenta plays a vital role in shaping the fetal environment, affecting fetal growth through the exchange of oxygen and nutrients, placental oxygen transport might be one of the environmental factors that also affect early human cortical growth. In this study, we aimed to assess the placental oxygen transport during maternal hyperoxia and its impact on fetal brain development using MRI in identical twins to control for genetic and maternal factors. We enrolled 9 pregnant subjects with monochorionic diamniotic twins (30.03 ± 2.39 gestational weeks [mean ± SD]). We observed that the fetuses with slower placental oxygen delivery had reduced volumetric and surface growth of the cerebral cortex. Moreover, when the difference between placenta oxygen delivery increased between the twin pairs, sulcal folding patterns were more divergent. Thus, there is a significant relationship between placental oxygen transport and fetal brain cortical growth and folding in monochorionic twins.

Indexed as

PlacentaTwins, MonozygoticFemaleFetal DevelopmentFetal Growth RetardationHumansOxygenPregnancyOxygencortical foldingfetal brainmonochorionic twinsMRIplacental oxygen transport

Identifiers

PMID37885155
PMCPMC11032198
OpenAlexW4387963402

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.