Evidence map›Paper›PMID 37885103›Full record

ArticleArthritis care & research2024

Clinical, Health-Related Quality of Life, and Gait Differences Among Obesity Classes in Adults With Knee Osteoarthritis.

Stephen P Messier, Malia E Gill, Shannon L Mihalko, Daniel P Beavers, Kate Queen, Gary D Miller, Elena Losina, Jeffrey N Katz, Richard F Loeser, Paul DeVita and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Arthritis care & research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Stephen P MessierWake Forest University, Winston-Salem, North Carolina.ORCID 0000-0002-7033-8459
Malia E GillWake Forest University, Winston-Salem, North Carolina.
Shannon L MihalkoWake Forest University, Winston-Salem, North Carolina.
Daniel P BeaversWake Forest University, Winston-Salem, North Carolina.
Kate QueenWhole Health Partners, Durham, North Carolina.
Gary D MillerWake Forest University, Winston-Salem, North Carolina.
Elena LosinaBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-3424-0892
Jeffrey N KatzBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0003-2104-4670
Richard F LoeserUniversity of North Carolina at Chapel Hill.ORCID 0000-0003-2832-6144
Paul DeVitaEast Carolina University, Greenville, North Carolina.
David J HunterUniversity of Sydney, Sydney, Australia.ORCID 0000-0003-3197-752X
Sara A QuandtWake Forest University, Winston-Salem, North Carolina.
Mary F LylesWake Forest University, Winston-Salem, North Carolina.
David HudsonWestern Carolina University, Cullowhee, North Carolina.
Leigh F CallahanUniversity of North Carolina at Chapel Hill.
Wake Forest University · USBrigham and Women's Hospital · USUniversity of North Carolina at Chapel Hill · USEast Carolina University · USHealthPartners · USThe University of Sydney · AUWestern Carolina University · US

Funding

Weight Loss and Exercise for Communities with Arthritis in North Carolina (WE-CAN)U01AR068658 · NIAMS · WAKE FOREST UNIVERSITY · PI CALLAHAN, LEIGH FLEMING, MESSIER, STEPHEN P · 2015 to 2017
$3.6M
NIAMS NIH HHS U01 AR068658
6 · The paper itself

Abstract

objectiveThe purpose of this study was to determine whether clinical, health-related quality of life (HRQL), and gait characteristics in adults with knee osteoarthritis (OA) differed by obesity category.

methodsThis cross-sectional analysis of 823 older adults (mean age 64.6 years, SD 7.8 years) with knee OA and overweight or obesity compared clinical, HRQL, and gait outcomes among obesity classifications (overweight or class I, body mass index [BMI] 27.0-34.9; class II, BMI 35.0-39.9; class III BMI ≥40.0).

resultsPatients with class III obesity had worse Western Ontario McMasters Universities Arthritis Index knee pain (0-20) than the overweight or class I (mean 8.6 vs 7.0; difference 1.5; 95% confidence interval [CI] 1.0-2.1; P < 0.0001) and class II (mean 8.6 vs 7.4; difference 1.1; 95% CI 0.6-1.7; P = 0.0002) obesity groups. The Short Form 36 physical HRQL measure was lower in the class III obesity group compared to the overweight or class I (mean 31.0 vs 37.3; difference -6.2; 95% CI -7.8 to -4.7; P < 0.0001) and class II (mean 31.0 vs 35.0; difference -3.9; 95% CI -5.6 to -2.2; P < 0.0001) obesity groups. The class III obesity group had a base of support (cm) during gait that was wider than that for the overweight or class I (mean 14.0 vs 11.6; difference 3.3; 95% CI 2.6-4.0; P < 0.0001) and class II (mean 14.0 vs 11.6; difference 2.4; 95% CI 1.6-3.2; P < 0.0001) obesity groups.

conclusionAmong adults with knee OA, those with class III obesity had significantly higher pain levels and worse physical HRQL and gait characteristics compared to adults with overweight or class I or class II obesity.

Indexed as

Osteoarthritis, KneeAgedBody Mass IndexCross-Sectional StudiesGaitHumansMiddle AgedObesityOverweightPainQuality of Life

Identifiers

PMID37885103
PMCPMC10963163
OpenAlexW4387966082

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.