ArticleBMC microbiology2023
Paralemnalia thyrsoides-associated fungi: phylogenetic diversity, cytotoxic potential, metabolomic profiling and docking analysis.
Article in BMC microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Cytotoxicity evaluation and metabolomic profiling of Spheciospongia vagabunda-associated fungi corroborated by in silico studies.Scientific reports · 2025Article
- Exploring the antitrypanosomal potential of rosemary root endophytic fungi with metabolomic profiling and molecular docking insights.Scientific reports · 2025Article
- Apium graveolens-associated Aspergillus sp.: metabolomic profiling and anti-MRSA potential supported by in silico studies.Microbial cell factories · 2025Article
- Study of marine microorganism metabolites: new resources for bioactive natural products.Frontiers in microbiology · 2023Review
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Authors and funding
12 authors.
Funding
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Abstract
backgroundCancer continues to be one of the biggest causes of death that affects human health. Chemical resistance is still a problem in conventional cancer treatments. Fortunately, numerous natural compounds originating from different microbes, including fungi, possess cytotoxic characteristics that are now well known. This study aims to investigate the anticancer prospects of five fungal strains that were cultivated and isolated from the Red Sea soft coral Paralemnalia thyrsoides. The in vitro cytotoxic potential of the ethyl acetate extracts of the different five isolates were evaluated using MTS assay against four cancer cell lines; A549, CT-26, MDA-MB-231, and U87. Metabolomics profiling of the different extracts using LC-HR-ESI-MS, besides molecular docking studies for the dereplicated compounds were performed to unveil the chemical profile and the cytotoxic mechanism of the soft coral associated fungi.
resultsThe five isolated fungal strains were identified as Penicillium griseofulvum (RD1), Cladosporium sphaerospermum (RD2), Cladosporium liminiforme (RD3), Penicillium chrysogenum (RD4), and Epicoccum nigrum (RD5). The in vitro study showed that the ethyl acetate extract of RD4 exhibited the strongest cytotoxic potency against three cancer cell lines A549, CT-26 and MDA-MB-231 with IC
conclusionOur results highlight the importance of soft coral-associated fungi as a promising source for anticancer metabolites for future drug discovery.
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