ArticleBMC genomics2023
Transcriptomic analysis reveals a tissue-specific loss of identity during ageing and cancer.
Article in BMC genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- A conserved post-maturity imbalance between housekeeping and integrative genome activity in aging.GeroScience · 2026Article
- A Pan-Cancer Analysis of microRNA Tissue Specificity and Its Association with Dysregulation.International journal of molecular sciences · 2026Article
- Tissue-Level Transcriptomic Entropy Reveals Organ-Specific Aging Patterns and Predicts Cancer Progression.Aging cell · 2026Article
- Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target.Nature reviews. Molecular cell biology · 2026Review
- TSProm: deep learning framework to predict tissue-specific regulatory logic.NAR genomics and bioinformatics · 2026Article
- Solid Tumors Pan Cancer Transcriptome: Tissue/Cancer specific expression groups at the Isoform-Level.bioRxiv : the preprint server for biology · 2026Article
- SIRT6 overexpression counteracts chromatin aging in the male murine liver.Nature communications · 2026Article
- Sex-specific nonlinear DNA methylation aging trajectories reveal biomarkers of cancer risk and inflammation.Genome biology · 2026Article
- TSProm: Deciphering the Genomic Context of Tissue Specificity.bioRxiv : the preprint server for biology · 2025Article
- An overview of contemporary theories of ageing.Nature cell biology · 2025Review
- A cellular identity crisis? Plasticity changes during aging and rejuvenation.Genes & development · 2024Review
- FEAtl: a comprehensive web-based expression atlas for functional genomics in tropical and subtropical fruit crops.BMC plant biology · 2024Article
- A comprehensive map of the aging blood methylome in humans.Genome biology · 2024Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionUnderstanding changes in cell identity in cancer and ageing is of great importance. In this work, we analyzed how gene expression changes in human tissues are associated with tissue specificity during cancer and ageing using transcriptome data from TCGA and GTEx.
resultsWe found significant downregulation of tissue-specific genes during ageing in 40% of the tissues analyzed, which suggests loss of tissue identity with age. For most cancer types, we have noted a consistent pattern of downregulation in genes that are specific to the tissue from which the tumor originated. Moreover, we observed in cancer an activation of genes not usually expressed in the tissue of origin as well as an upregulation of genes specific to other tissues. These patterns in cancer were associated with patient survival. The age of the patient, however, did not influence these patterns.
conclusionWe identified loss of cellular identity in 40% of the tissues analysed during human ageing, and a clear pattern in cancer, where during tumorigenesis cells express genes specific to other organs while suppressing the expression of genes from their original tissue. The loss of cellular identity observed in cancer is associated with prognosis and is not influenced by age, suggesting that it is a crucial stage in carcinogenesis.
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