Evidence map›Paper›PMID 37884860›Full record

Observational studyBMC infectious diseases2023

Identification of microorganisms by a rapid PCR panel from positive blood cultures leads to faster optimal antimicrobial therapy - a before-after study.

Jessica Agnetti, Andrea C Büchler, Michael Osthoff, Fabrice Helfenstein, Maja Weisser, Martin Siegemund, Stefano Bassetti, Roland Bingisser, Dirk J Schaefer, Martin Clauss and 5 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04156633 (Clinical Impact of Rapid Identification of Positive Blood Cultures vs. Internal Laboratory Standard), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04156633 completednot on this map

Clinical Impact of Rapid Identification of Positive Blood Cultures vs. Internal Laboratory Standard

TypeobservationalSponsorUniversity Hospital, Basel, SwitzerlandRan2019 to 2022Enrolled800ConditionsBloodstream InfectionsArmsconventional identification method: biochemical profiling or MALDI-TOF MS, new identification method: Biofire FilmArray© BCID panel, new identification method: metagenomic WGS
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Observational
  2. Article
  3. Detection of Fluconazole Resistance inJournal of fungi (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Article
  6. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jessica Agnetti *Clinical Bacteriology and Mycology, University Hospital Basel, Basel, Switzerland.
Andrea C Büchler *Infectious Diseases and Hospital Epidemiology, University of Basel and University Hospital Basel, Basel, Switzerland.
Michael OsthoffInternal Medicine, University of Basel and University Hospital Basel, Basel, Switzerland.
Fabrice HelfensteinDepartment of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland.
Maja WeisserInfectious Diseases and Hospital Epidemiology, University of Basel and University Hospital Basel, Basel, Switzerland.
Martin SiegemundIntensive Care Medicine, University Hospital Basel, Basel, Switzerland.
Stefano BassettiInternal Medicine, University of Basel and University Hospital Basel, Basel, Switzerland.
Roland BingisserEmergency Medicine, University Hospital Basel, Basel, Switzerland.
Dirk J SchaeferPlastic, Reconstructive, Aesthetic Surgery and Hand Surgery, University Hospital Basel, Basel, Switzerland.
Martin ClaussCenter for Musculoskeletal Infections (ZMSI), University Hospital Basel, Basel, Switzerland.
Vladimira HinicClinical Bacteriology and Mycology, University Hospital Basel, Basel, Switzerland.
Sarah Tschudin-SutterInfectious Diseases and Hospital Epidemiology, University of Basel and University Hospital Basel, Basel, Switzerland.
Veronika BättigInfectious Diseases and Hospital Epidemiology, University of Basel and University Hospital Basel, Basel, Switzerland.
Nina Khanna *Infectious Diseases and Hospital Epidemiology, University of Basel and University Hospital Basel, Basel, Switzerland.
Adrian Egli *Clinical Bacteriology and Mycology, University Hospital Basel, Basel, Switzerland. aegli@imm.uzh.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe BioFire® FilmArray® Blood Culture Identification Panel 1 (BF-FA-BCIP) detects microorganisms with high accuracy in positive blood cultures (BC) - a key step in the management of patients with suspected bacteraemia. We aimed to compare the time to optimal antimicrobial therapy (OAT) for the BF-FA-BCIP vs. standard culture-based identification.

methodsIn this retrospective single-centre study with a before-after design, 386 positive BC cases with identification by BF-FA-BCIP were compared to 414 controls with culture-based identification. The primary endpoint was the time from BC sampling to OAT. Secondary endpoints were time to effective therapy, length of stay, (re-)admission to ICU, in-hospital and 30-day mortality. Outcomes were assessed using Cox proportional hazard models and logistic regressions.

resultsBaseline characteristics of included adult inpatients were comparable. Main sources of bacteraemia were urinary tract and intra-abdominal infection (19.2% vs. 22.0% and 16.8% vs. 15.7%, for cases and controls, respectively). Median (95%CI) time to OAT was 25.5 (21.0-31.2) hours with BF-FA-BCIP compared to 45.7 (37.7-51.4) hours with culture-based identification. We observed no significant difference for secondary outcomes.

conclusionsRapid microorganism identification by BF-FA-BCIP was associated with a median 20-h earlier initiation of OAT in patients with positive BC. No impact on length of stay and mortality was noted.

trial registrationClinicaltrials.gov, NCT04156633, registered on November 5, 2019.

Indexed as

Anti-Infective AgentsBacteremiaAdultAnti-Bacterial AgentsBlood CultureControlled Before-After StudiesHumansPolymerase Chain ReactionRetrospective StudiesAnti-Bacterial AgentsAnti-Infective AgentsAnti-infective agentsAntimicrobial stewardshipBioFire FilmArrayBlood culturePCR panelSepsis

Identifiers

PMID37884860
PMCPMC10601314

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.