Evidence map›Paper›PMID 37884839›Full record

ArticleJournal of general internal medicine2024

Risk of Suicide-Related Outcomes After SARS-COV-2 Infection: Results from a Nationwide Observational Matched Cohort of US Veterans.

Denise M Hynes, Meike Niederhausen, Jason I Chen, Troy A Shahoumian, Mazhgan Rowneki, Alex Hickok, Megan Shepherd-Banigan, Eric J Hawkins, Jennifer Naylor, Alan Teo and 15 more

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Journal of general internal medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05394025 (COVID-19 Observational Research Collaboratory - Long-Term Outcomes), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05394025 completednot on this map

COVID-19 Observational Research Collaboratory - Long-Term Outcomes (LTO) Study

TypeobservationalSponsorVA Office of Research and DevelopmentRan2022 to 2024Enrolled479ConditionsCOVID-19, SARS-CoV-2 Infection
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Change in frailty among older COVID-19 survivors.Journal of the American Geriatrics Society · 2024
    Observational
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 11 institutions in 1 country.

Denise M HynesCenter to Improve Veteran Involvement in Care (CIVIC), VA Portland Health Care System (HCS), Portland, OR, USA. Denise.Hynes@va.gov.ORCID 0000-0002-6436-7157
Meike NiederhausenCenter to Improve Veteran Involvement in Care (CIVIC), VA Portland Health Care System (HCS), Portland, OR, USA.
Jason I ChenCenter to Improve Veteran Involvement in Care (CIVIC), VA Portland Health Care System (HCS), Portland, OR, USA.
Troy A ShahoumianVHA, Patient Care Services: Health Solutions, Washington, DC, USA.
Mazhgan RownekiCenter to Improve Veteran Involvement in Care (CIVIC), VA Portland Health Care System (HCS), Portland, OR, USA.
Alex HickokCenter to Improve Veteran Involvement in Care (CIVIC), VA Portland Health Care System (HCS), Portland, OR, USA.
Megan Shepherd-BaniganCenter of Innovation to Accelerate Discovery and Practice Transformation (ADAPT), Durham VA HCS, Durham, NC, USA.
Eric J HawkinsCenter of Innovation for Veteran-Centered and Value-Driven Care, VA Puget Sound HCS, Seattle, WA, USA.
Jennifer NaylorSchool of Medicine, Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Alan TeoCenter to Improve Veteran Involvement in Care (CIVIC), VA Portland Health Care System (HCS), Portland, OR, USA.
Diana J GovierCenter to Improve Veteran Involvement in Care (CIVIC), VA Portland Health Care System (HCS), Portland, OR, USA.
Kristin BerryCenter of Innovation for Veteran-Centered and Value-Driven Care, VA Puget Sound HCS, Seattle, WA, USA.
Holly McCreadyCenter to Improve Veteran Involvement in Care (CIVIC), VA Portland Health Care System (HCS), Portland, OR, USA.
Thomas F OsborneVA Palo Alto HCS, Palo Alto, CA, USA.
Edwin WongCenter of Innovation for Veteran-Centered and Value-Driven Care, VA Puget Sound HCS, Seattle, WA, USA.
Paul L HebertCenter of Innovation for Veteran-Centered and Value-Driven Care, VA Puget Sound HCS, Seattle, WA, USA.
Valerie A SmithCenter of Innovation to Accelerate Discovery and Practice Transformation (ADAPT), Durham VA HCS, Durham, NC, USA.
C Barrett BowlingCenter of Innovation to Accelerate Discovery and Practice Transformation (ADAPT), Durham VA HCS, Durham, NC, USA.
Edward J BoykoSeattle Epidemiologic Research Information Center, VA Puget Sound HCS, Seattle, WA, USA.
George N IoannouCenter of Innovation for Veteran-Centered and Value-Driven Care, VA Puget Sound HCS, Seattle, WA, USA.
Theodore J IwashynaDepartments of Medicine and Health Policy and Management, Johns Hopkins University, Baltimore, MD, USA.
Matthew L MaciejewskiCenter of Innovation to Accelerate Discovery and Practice Transformation (ADAPT), Durham VA HCS, Durham, NC, USA.
Ann M O'HareCenter of Innovation for Veteran-Centered and Value-Driven Care, VA Puget Sound HCS, Seattle, WA, USA.
Elizabeth M VigliantiCenter for Clinical Management Research, VA Ann Arbor HCS, Ann Arbor, MI, USA.
Amy S-B BohnertCenter for Clinical Management Research, VA Ann Arbor HCS, Ann Arbor, MI, USA.
Duke University · USVA Portland Health Care System · USUniversity of Washington · USVA Puget Sound Health Care System · USPortland State University · USUniversity of Michigan · USJohns Hopkins University · USOffice of Patient Care Services · USOregon State University · USUniversity of Puget Sound · USVA Palo Alto Health Care System · US

Funding

Improving Analysis of Endogenous Multimodal Treatments for Use in Geriatrics Health Outcomes StudiesI01HX002237 · VA · VA BOSTON HEALTH CARE SYSTEM · PI GARRIDO, MELISSA M · 2018 to 2021
–
HSR&D Senior Research Career Scientist AwardIK6HX003395 · VA · PORTLAND VA MEDICAL CENTER · PI Denise M. Hynes · 2021 to 2026
–
HSRD VA IK6 HX003395HSRD VA SDR 02-237
6 · The paper itself

Abstract

backgroundNegative mental health-related effects of SARS-COV-2 infection are increasingly evident. However, the impact on suicide-related outcomes is poorly understood, especially among populations at elevated risk.

objectiveTo determine risk of suicide attempts and other self-directed violence (SDV) after SARS-COV-2 infection in a high-risk population.

designWe employed an observational design supported by comprehensive electronic health records from the Veterans Health Administration (VHA) to examine the association of SARS-COV-2 infection with suicide attempts and other SDV within one year of infection. Veterans with SARS-COV-2 infections were matched 1:5 with non-infected comparators each month. Three periods after index were evaluated: days 1-30, days 31-365, and days 1-365.

participantsVHA patients infected with SARS-COV-2 between March 1, 2020 and March 31, 2021 and matched non-infected Veteran comparators. MAIN MEASURES: Suicide attempt and other SDV events for the COVID-19 and non-infected comparator groups were analyzed using incidence rates per 100,000 person years and hazard ratios from Cox regressions modeling time from matched index date to first event. Subgroups were also examined. KEY

results198,938 veterans with SARS-COV-2 (COVID-19 group) and 992,036 comparators were included. Unadjusted one-year incidence per 100,000 for suicide attempt and other SDV was higher among the COVID-19 group: 355 vs 250 and 327 vs 235, respectively. The COVID-19 group had higher risk than comparators for suicide attempts: days 1-30 hazard ratio (HR) = 2.54 (CI:2.05, 3.15), days 31-365 HR = 1.30 (CI:1.19, 1.43) and days 1-365 HR = 1.41 (CI:1.30, 1.54), and for other SDV: days 1-30 HR = 1.94 (CI:1.51, 2.49), days 31-365 HR = 1.32 (CI:1.20, 1.45) and days 1-365 HR = 1.38 (CI:1.26, 1.51).

conclusionsCOVID-19 patients had higher risks of both suicide attempts and other forms of SDV compared to uninfected comparators, which persisted for at least one year after infection. Results support suicide risk screening of those infected with SARS-COV-2 to identify opportunities to prevent self-harm.

Indexed as

COVID-19VeteransElectronic Health RecordsHumansSARS-CoV-2Suicide, AttemptedCOVID-19mental healthself-directed violencesuicide attemptveterans

Identifiers

PMID37884839
PMCPMC10973286
OpenAlexW4387965022

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.