Evidence map›Paper›PMID 37884682›Full record

ReviewBritish journal of cancer2024

Supporting gut health with medicinal cannabis in people with advanced cancer: potential benefits and challenges.

Hannah R Wardill, Luke T Wooley, Olivia M Bellas, Katrina Cao, Courtney B Cross, Madele van Dyk, Ganessan Kichenadasse, Joanne M Bowen, Andrew C W Zannettino, Sepehr Shakib and 5 more

Open access · hybridAbstract readReview
In one paragraph

Review in British journal of cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Hannah R WardillThe School of Biomedicine, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia. hannah.wardill@adelaide.edu.au.ORCID 0000-0002-6613-3661
Luke T WooleyThe School of Biomedicine, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.
Olivia M BellasThe School of Biomedicine, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.
Katrina CaoSupportive Oncology Research Group, Precision Cancer Medicine Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.
Courtney B CrossThe School of Biomedicine, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.
Madele van DykFlinders Centre for Innovation in Cancer, Flinders Medical Centre/Flinders University, SA Health, Adelaide, SA, Australia.
Ganessan KichenadasseFlinders Centre for Innovation in Cancer, Flinders Medical Centre/Flinders University, SA Health, Adelaide, SA, Australia.
Joanne M BowenThe School of Biomedicine, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.
Andrew C W ZannettinoThe School of Biomedicine, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.ORCID 0000-0002-6646-6167
Sepehr ShakibThe School of Biomedicine, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.
Gregory B CrawfordNorthern Adelaide Local Health Network South Australia, SA Health, Adelaide, SA, Australia.
Jaroslav BoublikLeafCann Group Pty Ltd, Coolum Beach, QLD, Australia.
Mellar M DavisThe Geisinger Commonwealth School of Medicine, Scranton, PA, USA.
Scott D SmidThe School of Biomedicine, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.
Timothy J PriceAdelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.ORCID 0000-0002-3922-2693
The University of Adelaide · AUSouth Australian Health and Medical Research Institute · AUFlinders University · AUGeisinger Commonwealth School of Medicine · USIP Australia · AUQueen Elizabeth Hospital · AUSA Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The side effects of cancer therapy continue to cause significant health and cost burden to the patient, their friends and family, and governments. A major barrier in the way in which these side effects are managed is the highly siloed mentality that results in a fragmented approach to symptom control. Increasingly, it is appreciated that many symptoms are manifestations of common underlying pathobiology, with changes in the gastrointestinal environment a key driver for many symptom sequelae. Breakdown of the mucosal barrier (mucositis) is a common and early side effect of many anti-cancer agents, known to contribute (in part) to a range of highly burdensome symptoms such as diarrhoea, nausea, vomiting, infection, malnutrition, fatigue, depression, and insomnia. Here, we outline a rationale for how, based on its already documented effects on the gastrointestinal microenvironment, medicinal cannabis could be used to control mucositis and prevent the constellation of symptoms with which it is associated. We will provide a brief update on the current state of evidence on medicinal cannabis in cancer care and outline the potential benefits (and challenges) of using medicinal cannabis during active cancer therapy.

Indexed as

Medical MarijuanaMucositisNeoplasmsHumansNauseaTumor MicroenvironmentVomitingMedical Marijuana

Identifiers

PMID37884682
PMCPMC10781684
OpenAlexW4387955639

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.