ArticleNature communications2023
Early selection of task-relevant features through population gating.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Sensorimotor remapping drives task specialization in prefrontal cortex.Nature communications · 2026Article
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- Dynamically Updated Task Rules Reshape Sensory Processing Across Cortical Hierarchies of the Posterior Parietal Cortex and Primary Auditory Cortex.Neuroscience bulletin · 2026Article
- Disinhibitory signaling enables flexible coding of top-down information in cortical networks.PLoS biology · 2026Article
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- Neural dynamics outside task-coding dimensions drive decision trajectories through transient amplification.bioRxiv : the preprint server for biology · 2025Article
- Hippocampal-Prefrontal Communication Subspaces Align with Behavioral and Network Patterns in a Spatial Memory Task.eNeuro · 2025Article
- A solvable neural circuit model revealing the dynamical principle of non-optimal temporal weighting in perceptual decision making.Journal of computational neuroscience · 2025Article
- Measuring Stimulus Information Transfer Between Neural Populations Through the Communication Subspace.Neural computation · 2025Article
- Stochastic activity in low-rank recurrent neural networks.PLoS computational biology · 2025Article
- Article
- High-dimensional neuronal activity from low-dimensional latent dynamics: a solvable model.bioRxiv : the preprint server for biology · 2025Article
- Structure of activity in multiregion recurrent neural networks.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- A neural implementation model of feedback-based motor learning.Nature communications · 2025Article
- The information bottleneck as a principle underlying multi-area cortical representations during decision-making.bioRxiv : the preprint server for biology · 2025Article
- Single-unit activations confer inductive biases for emergent circuit solutions to cognitive tasks.Nature machine intelligence · 2025Article
- Exploring the n-back task: insights, applications, and future directions.Frontiers in human neuroscience · 2025Review
- Inferring context-dependent computations through linear approximations of prefrontal cortex dynamics.Science advances · 2024Article
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Authors and funding
6 authors.
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Abstract
Brains can gracefully weed out irrelevant stimuli to guide behavior. This feat is believed to rely on a progressive selection of task-relevant stimuli across the cortical hierarchy, but the specific across-area interactions enabling stimulus selection are still unclear. Here, we propose that population gating, occurring within primary auditory cortex (A1) but controlled by top-down inputs from prelimbic region of medial prefrontal cortex (mPFC), can support across-area stimulus selection. Examining single-unit activity recorded while rats performed an auditory context-dependent task, we found that A1 encoded relevant and irrelevant stimuli along a common dimension of its neural space. Yet, the relevant stimulus encoding was enhanced along an extra dimension. In turn, mPFC encoded only the stimulus relevant to the ongoing context. To identify candidate mechanisms for stimulus selection within A1, we reverse-engineered low-rank RNNs trained on a similar task. Our analyses predicted that two context-modulated neural populations gated their preferred stimulus in opposite contexts, which we confirmed in further analyses of A1. Finally, we show in a two-region RNN how population gating within A1 could be controlled by top-down inputs from PFC, enabling flexible across-area communication despite fixed inter-areal connectivity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.