Observational studyArchives of physical medicine and rehabilitation2024
Post-stroke Depressive Symptoms and Cognitive Performances: A Network Analysis.
Observational study in Archives of physical medicine and rehabilitation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Effects of noninvasive brain stimulation in the treatment of poststroke depression: an overview of systematic reviews.Frontiers in neurologyPooled it
- Symptom Network and Lesion Mapping of Post-Stroke Depression, Cognitive Impairment, and Dysfunction: A Multicenter Cohort Study.Brain and behavior · 2026Observational
- Prevalence of depression and cognitive impairment and their inter-relationship and association with quality of life among older stroke survivors: the findings of a national survey in China.Stroke and vascular neurology · 2026Article
- Cognitive, Functional, and Emotional Recovery in Patients with Stroke: A Multidimensional Prospective Analysis.Neurology international · 2025Article
- Cognitive and Emotional Impairments in Acute Post-Stroke Patients-A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2025Article
- A Network Analysis of Food Intake and Cognitive Function in Older Adults with Multimorbidity: A National Cross-Sectional Study.Nutrients · 2025Article
- Relationships Between Symptom Distress and Positive Psychological Variables Among Stroke Patients: A Network Analysis.International journal of general medicine · 2025Article
- Infarct volume as a predictor and therapeutic target in post-stroke cognitive impairment.Frontiers in medicine · 2025Review
- Longitudinal Associations Between Depression Symptoms and Cognitive Functions in Chinese Older Adults: A Cross-Lagged Panel Network Analysis.Depression and anxiety · 2025Article
- Effects of Virtual Rehabilitation Training on Post-Stroke Executive and Praxis Skills and Depression Symptoms: A Quasi-Randomised Clinical Trial.Diagnostics (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo examine the relationships between post-stroke depression and cognition using network analysis. In particular, we identified central depressive symptoms, central cognitive performances, and bridge components that connect these 2 constructs.
designAn observational study. We applied network analysis to analyze baseline data to visualize and quantify the relationships between depression and cognition.
settingHome and Community.
participants202 participants with mild-to-moderate stroke (N=202; mean age: 59.7 years; 55% men; 55% Whites; 90% ischemic stroke).
interventionNot applicable.
main outcome measuresPatient Health Questionnaire (PHQ-8) for depressive symptoms and the NIH Toolbox Cognitive Battery for cognitive performances.
resultsDepressive symptoms were positively intercorrelated with the network, with symptoms from similar domains clustered together. Mood (expected influence=1.58), concentration (expected influence=0.67), and guilt (expected influence=0.63) were the top 3 central depressive symptoms. Cognitive performances also showed similar network patterns, with executive function (expected influence=0.89), expressive language (expected influence=0.68), and processing speed (expected influence=0.48) identified as the top 3 central cognitive performances. Psychomotor functioning (bridge expected influence=2.49) and attention (bridge expected influence=1.10) were the components connecting depression and cognition.
conclusionsThe central and bridge components identified in this study might serve as targets for interventions against these deficits. Future trials are needed to compare the effectiveness of interventions targeting the central and bridge components vs general interventions treating depression and cognitive impairment as a homogenous clinical syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.