Evidence map›Paper›PMID 37884028›Full record

ArticleNature medicine2023

Evidence for a role of Anopheles stephensi in the spread of drug- and diagnosis-resistant malaria in Africa.

Tadele Emiru, Dejene Getachew, Maxwell Murphy, Luigi Sedda, Legesse Alamerie Ejigu, Mikiyas Gebremichael Bulto, Isabel Byrne, Mulugeta Demisse, Melat Abdo, Wakweya Chali and 23 more

Open access · hybridAbstract read
In one paragraph

Article in Nature medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 4 pooled it
46.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 4 syntheses or guidelines pooled it, 159 citations in OpenAlex.

  1. Pooled it
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  4. Pooled it
  5. Review
  6. Article
  7. Article
  8. Field evaluation of SumiLarvMalaria journal · 2026
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  17. Historical Overview of the Bionomics ofJournal of arthropod-borne diseases · 2026
    Review
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  19. Article
  20. Article

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 11 institutions in 4 countries.

Tadele Emiru *Armauer Hansen Research Institute, Addis Ababa, Ethiopia.
Dejene Getachew *Adama Science and Technology University, Adama, Ethiopia.
Maxwell Murphy *EPPIcenter program, Division of HIV, ID and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-0332-4388
Luigi Sedda *Lancaster Ecology and Epidemiology Group, Lancaster Medical School, Lancaster University, Lancaster, UK.ORCID 0000-0002-9271-6596
Legesse Alamerie EjiguArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Mikiyas Gebremichael BultoArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Isabel ByrneLondon School of Hygiene and Tropical Medicine, London, UK.
Mulugeta DemisseArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Melat AbdoArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Wakweya ChaliArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Aaron ElliottEPPIcenter program, Division of HIV, ID and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.
Eric Neubauer VickersEPPIcenter program, Division of HIV, ID and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.
Andrés Aranda-DíazEPPIcenter program, Division of HIV, ID and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.
Lina AlemayehuArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Sinknesh W BehakseraArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Gutema JebessaArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Hunduma DinkaAdama Science and Technology University, Adama, Ethiopia.
Tizita TsegayeArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Hiwot TekaU.S. President's Malaria Initiative, USAID, Addis Ababa, Ethiopia.
Sheleme ChibsaU.S. President's Malaria Initiative, USAID, Addis Ababa, Ethiopia.
Peter MumbaU.S. President's Malaria Initiative, USAID, Addis Ababa, Ethiopia.
Samuel GirmaU.S. President's Malaria Initiative, USAID, Addis Ababa, Ethiopia.
Jimee HwangU.S. President's Malaria Initiative, Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0002-9890-2664
Melissa YoshimizuU.S. President's Malaria Initiative, USAID, Washington DC, DC, USA.
Alice SutcliffeU.S. President's Malaria Initiative, Entomology Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA.
Hiwot Solomon TaffeseFederal Ministry of Health, Addis Ababa, Ethiopia.
Gudissa Aseffa BayissaFederal Ministry of Health, Addis Ababa, Ethiopia.
Sarah ZohdyU.S. President's Malaria Initiative, Entomology Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA.
Jon Eric TongrenU.S. President's Malaria Initiative, Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0002-4879-3228
Chris DrakeleyLondon School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0003-4863-075X
Bryan GreenhouseEPPIcenter program, Division of HIV, ID and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.
Teun BousemaRadboudumc, Nijmegen, the Netherlands.ORCID 0000-0003-2666-094X
Fitsum G TadesseArmauer Hansen Research Institute, Addis Ababa, Ethiopia. fitsum.girma@ahri.gov.et.ORCID 0000-0003-1931-1442
Armauer Hansen Research Institute · ETUniversity of California, San Francisco · USCenters for Disease Control and Prevention · USInternational Trachoma Initiative · ETAdama Science and Technology University · ETFederal Ministry of Health · ETLondon School of Hygiene & Tropical Medicine · GBRadboud University Nijmegen · NLLancaster University · GBUnited States Agency for International Development · USUniversity of London · GB

Funding

Mentoring translational scientists in international infectious disease researchK24AI144048 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bryan R Greenhouse · 2019 to 2026
$1.6M
NIAID NIH HHS K24 AI144048Wellcome Trust
6 · The paper itself

Abstract

Anopheles stephensi, an Asian malaria vector, continues to expand across Africa. The vector is now firmly established in urban settings in the Horn of Africa. Its presence in areas where malaria resurged suggested a possible role in causing malaria outbreaks. Here, using a prospective case-control design, we investigated the role of An. stephensi in transmission following a malaria outbreak in Dire Dawa, Ethiopia in April-July 2022. Screening contacts of patients with malaria and febrile controls revealed spatial clustering of Plasmodium falciparum infections around patients with malaria in strong association with the presence of An. stephensi in the household vicinity. Plasmodium sporozoites were detected in these mosquitoes. This outbreak involved clonal propagation of parasites with molecular signatures of artemisinin and diagnostic resistance. To our knowledge, this study provides the strongest evidence so far for a role of An. stephensi in driving an urban malaria outbreak in Africa, highlighting the major public health threat posed by this fast-spreading mosquito.

Indexed as

AnophelesMalariaMalaria, FalciparumAnimalsEthiopiaHumansMosquito Vectors

Identifiers

PMID37884028
PMCPMC10719088
OpenAlexW4387956265

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.