SynthesisCell host & microbe2023
Extension of the Segatella copri complex to 13 species with distinct large extrachromosomal elements and associations with host conditions.
Synthesis in Cell host & microbe, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- Intrinsic chicory root fibers modulate colonic microbial butyrate-producing pathways and improve insulin sensitivity in individuals with obesity.Cell reports. Medicine · 2025Trial
- Bridging the gap:Gut microbes · 2026Review
- Gut microbiomes of tribal communities in India vary with dairy and grain consumption.Gut microbes · 2026Article
- A high-resolution spatial model of the primate gut microbiome defines niche-specific functions and host-adapted microbial metabolism.Gut microbes · 2026Article
- Extensive genomic diversity in Desulfovibrio reveals species-specific functional traits associated with disease.Nature communications · 2026Article
- Synergy between Enterobacteriaceae and diet mediates competition between dominant Bacteroidales in the human gut.Nature microbiology · 2026Article
- Article
- Global and local trajectories of infant gut microbiota development in Bangladesh across the COVID-19 pandemic.mSystems · 2026Article
- Review
- Re-Emerging Bacterial Pathogens, Resistance Genes and Promising Bioindicators in Raw and Treated Sewage-Addressing a Known Issue from a Different Angle and Perspective.Microorganisms · 2026Article
- From sequence space to ecological function: microbiome-derived antimicrobial peptides as community effectors and therapeutic leads.Essays in biochemistry · 2026Review
- A roadmap to create FAIR collections of microbial strains.Nature microbiology · 2026Review
- Insights from adult gut microbiota using the Estonian cohort as a uniform model.Scientific reports · 2026Article
- High-resolution metagenome assembly for modern long reads with myloasm.Nature biotechnology · 2026Article
- Identification of antimicrobial peptides from ancient gut microbiomes.Nature communications · 2026Article
- Gut microbiota of sprint athletes: signature microbes and dietary links.Frontiers in nutrition · 2026Article
- Article
- Factors affecting the gut microbiota of rural residents under different physical activity levels: a cross-sectional study.Frontiers in microbiology · 2026Article
- Dietary transition to an Indigenous Greenlandic diet induces instant shifts in gut microbiota composition - a pilot intervention study.Frontiers in microbiomes · 2026Article
- Contamination-controlled upper gastrointestinal microbiota profiling reveals salivary-duodenal community types linked to opportunistic pathogen carriage and inflammation.Gut microbes · 2025Article
Corrections and comments
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Authors and funding
25 authors.
Funding
Abstract
The Segatella copri (formerly Prevotella copri) complex (ScC) comprises taxa that are key members of the human gut microbiome. It was previously described to contain four distinct phylogenetic clades. Combining targeted isolation with large-scale metagenomic analysis, we defined 13 distinct Segatella copri-related species, expanding the ScC complex beyond four clades. Complete genome reconstruction of thirteen strains from seven species unveiled the presence of genetically diverse large circular extrachromosomal elements. These elements are consistently present in most ScC species, contributing to intra- and inter-species diversities. The nine species-level clades present in humans display striking differences in prevalence and intra-species genetic makeup across human populations. Based on a meta-analysis, we found reproducible associations between members of ScC and the male sex and positive correlations with lower visceral fat and favorable markers of cardiometabolic health. Our work uncovers genomic diversity within ScC, facilitating a better characterization of the human microbiome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.