Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2024
Long-Term Results of Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy: The Randomized Phase II OPRA Trial.
Registry-linked trialOpen access · greenAbstract readRandomized Controlled TrialClinical Trial, Phase II
In one paragraph
Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07192627 (Selective Endoscopic Resection vs. Surveillance Following CRT for Rectal Cancer), which is not on this map. Cited by 204 papers, 10 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
204citing papers in PubMed, 10 pooled it
63.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Selective Endoscopic Resection vs. Surveillance Following CRT for Rectal Cancer: 1-Year Oncologic and Functional Outcomes
Who cites it
204 citing papers in PubMed, 10 syntheses or guidelines pooled it, 277 citations in OpenAlex.
- A systematic review and meta-analysis of preoperative MRI-based pelvimetry in predicting surgical difficulty in rectal cancer: Implications for personalised surgical planning.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026Pooled it
- Methodological challenges in surgical randomized trials: systematic review of rectal cancer studies.BJS open · 2026Pooled it
- Systematic review and meta-analysis comparing postoperative and oncological outcomes between local excision plus radiotherapy versus total mesorectal excision for rectal cancer.World journal of surgical oncology · 2026Pooled it
- Pooled it
- SEOM-GEMCAD-TTD clinical guidelines for localized rectal cancer (2025).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Guideline
- The Korean Rectal Cancer Multidisciplinary Committee Clinical Practice Guidelines for Rectal Cancer version 2.0.Annals of coloproctology · 2026Guideline
- Neoadjuvant therapy combined with immunotherapy for anal sphincter preservation rate, clinical efficacy, and safety in rectal cancer patients: a meta-analysis.Frontiers in oncology · 2026Pooled it
- The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of colorectal cancer, 2024 update.Cancer communications (London, England) · 2025Guideline
- Neoadjuvant chemoradiotherapy in combination with deep regional hyperthermia followed by surgery for rectal cancer: a systematic review and meta-analysis.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025Pooled it
- Economic Evaluation of 'Watch and Wait' Following Neoadjuvant Therapy in Locally Advanced Rectal Cancer: A Systematic Review.Annals of surgical oncology · 2025Pooled it
- Organ Preservation and Quality of Life After Total Neoadjuvant Treatment in Rectal Cancer.JAMA network open · 2026Trial
- Multicenter phase II study of neoadjuvant FOLFOXIRI followed by concurrent chemoradiotherapy in Chinese patients with high-risk rectal cancer.The oncologist · 2026Trial
- Chemoradiotherapy and transanal endoscopic surgery versus transanal endoscopic surgery alone in T1N0M0 rectal cancer: a multicenter, randomized, controlled, phase III clinical trial (TAUTEM-T1 study).International journal of colorectal disease · 2026Trial
- Minimum 18-week chemotherapy improves survival in locally advanced rectal cancer after neoadjuvant radiotherapy: a post hoc analysis of the STELLAR trial.BMC medicine · 2026Trial
- Association of Lateral Pelvic Lymph Nodes with Disease Recurrence and Organ Preservation in Patients with Distal Rectal Adenocarcinoma Treated with Total Neoadjuvant Therapy.Annals of surgery · 2025Trial
- Nonoperative Management of Mismatch Repair-Deficient Tumors.The New England journal of medicine · 2025Trial
- Survival among patients treated with total mesorectal excision or selective watch-and-wait after total neoadjuvant therapy: a pooled analysis of the CAO/ARO/AIO-12 and OPRA randomized phase II trials.Annals of oncology : official journal of the European Society for Medical Oncology · 2025Trial
- Trial
- Chemoradiotherapy plus induction or consolidation chemotherapy as total neoadjuvant therapy for locally advanced rectal cancer: Pooled analysis of the CAO/ARO/AIO-12 and the OPRA randomized phase 2 trials.European journal of cancer (Oxford, England : 1990) · 2024Trial
- Baseline MRI predictors of successful organ preservation in the Organ Preservation in Rectal Adenocarcinoma (OPRA) trial.The British journal of surgery · 2024Trial
144 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
43 authors at 20 institutions in 1 country.
Floris S VerheijDepartment of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0001-7834-7336
Dana M OmerDepartment of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, NY.
Hannah WilliamsDepartment of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, NY.
Sabrina T LinDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0001-7535-2535
Li-Xuan QinDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-9367-3807
James T BuckleyDepartment of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, NY.
Hannah M ThompsonDepartment of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, NY.
Jonathan B YuvalDepartment of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-9251-8303
Jin K KimDepartment of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-4373-1431
Richard F DunneDepartment of Medicine, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY.ORCID 0000-0001-6608-660X
Jorge MarcetDivision of Colon and Rectal Surgery, Department of Surgery, University of South Florida, Tampa, FL.ORCID 0000-0003-3728-8741
Peter CataldoDivision of General Surgery, Department of Surgery, University of Vermont, Burlington, VT.
Blase PoliteDepartment of Medicine, Comprehensive Cancer Center, University of Chicago, Chicago, IL.ORCID 0000-0001-8743-8096
Daniel O HerzigDivision of Gastrointestinal and General Surgery, Oregon Health and Science University, Portland, OR.ORCID 0000-0001-8039-2136
David LiskaDepartment of Colorectal Surgery, Cleveland Clinic, Cleveland, OH.ORCID 0000-0002-8632-6065
Samuel OommenDivision of Gastrointestinal Oncology, John Muir Cancer Institute, John Muir Health, Walnut Creek, CA.
Charles M FrielDivision of General Surgery, Department of Surgery, University of Virginia, Charlottesville, VA.
Charles TernentMethodist Hospital Physicians Clinic Colon and Rectal Surgery and The Creighton University Clinical Research Center, Omaha, NE.ORCID 0000-0003-0050-9723
Andrew L CovelerDepartment of Medicine, Fred Hutch Cancer Center, University of Washington, Seattle, WA.ORCID 0000-0003-1710-5637
Steven HuntDepartment of Surgery, Washington University School of Medicine, St Louis, MO.
Anita GregoryDepartment of Surgery, St Joseph Hospital Orange County, Orange, CA.
Madhulika G VarmaSection of Colon and Rectal Surgery, Department of Surgery, University of California, San Francisco, San Francisco, CA.ORCID 0000-0003-1679-926X
Brian L BelloDivision of Colorectal Surgery, Department of Surgery, Medstar Washington Hospital Center, Washington, DC.
Joseph C CarmichaelDivision of Colon and Rectal Surgery, Department of Surgery, University of California, Irvine, Irvine, CA.ORCID 0000-0003-2738-7113
John KraussDepartment of Medicine, Rogel Cancer Center at the University of Michigan, Ann Arbor, MI.ORCID 0000-0002-5197-736X
Ana GleisnerDivision of Surgical Oncology, Department of Surgery, University of Colorado, Denver, CO.
José G GuillemDivision of Gastrointestinal Surgery, Department of Surgery, University of North Carolina, Chapel Hill, NC.ORCID 0009-0002-3510-8276
Larissa TempleDivision of Colorectal Surgery, Department of Surgery, University of Rochester Medical Center, Rochester, NY.
Karyn A GoodmanDepartment of Radiation Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0002-4576-6355
Neil H SegalDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-3047-2303
Andrea CercekDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-5054-8192
Rona YaegerDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-7233-5454
Garrett M NashDepartment of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, NY.
Maria WidmarDepartment of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, NY.
Iris H WeiDepartment of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0001-9006-9105
Emmanouil P PappouDepartment of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-8735-1852
Martin R WeiserDepartment of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-9577-7984
Philip B PatyDepartment of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-7045-2112
J Joshua SmithDepartment of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0003-2538-5456
Abraham J WuDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-2597-7091
Marc J GollubDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-6008-0730
Leonard B SaltzDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0001-8353-4670
Julio Garcia-AguilarDepartment of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0003-2451-0948
Memorial Sloan Kettering Cancer Center · USUniversity of Rochester Medical Center · USCleveland Clinic · USCreighton University · USIcahn School of Medicine at Mount Sinai · USJohn Muir Health · USMedStar Washington Hospital Center · USOregon Health & Science University · USSt. Joseph Hospital · USUniversity of California, Irvine · USUniversity of California, San Francisco · USUniversity of Chicago · USUniversity of Colorado Denver · USUniversity of Michigan · USUniversity of North Carolina at Chapel Hill · USUniversity of South Florida · USUniversity of Vermont · USUniversity of Virginia · USUniversity of Washington · USWashington University in St. Louis · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MSURGICAL ONCOLOGY RESEARCH TRAINING PROGRAMT32CA009501 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Babak J Mehrara · 1985 to 2026
$7.7MOrgan Preservation in Rectal AdenocarcinomaR01CA182551 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI GARCIA-AGUILAR, JULIO · 2014 to 2018
$3.1MNCI NIH HHS P30 CA008748NCI NIH HHS R01 CA182551NCI NIH HHS T32 CA009501
Abstract
PubMed holds no abstract for this paper.
Indexed as
AdenocarcinomaRectal NeoplasmsChemoradiotherapyHumansNeoadjuvant TherapyNeoplasm Recurrence, LocalNeoplasm StagingOrgan PreservationTreatment Outcome
Identifiers
What OpenQuestion holds
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Registered trials
NCT07192627ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.