Evidence map›Paper›PMID 37883719›Full record

ArticleJCO precision oncology2023

Intronic Germline

Claudette R Fraire, Paige R Mallinger, Jessica N Hatton, Jung Kim, David S Dickens, Peter A Argenta, Samuel Milanovich, Taylor Hartshorne, David J Carey, Jeremy S Haley and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JCO precision oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Prognostic Significance of GermlineJCO precision oncology · 2025
    Article
  4. Review
  5. Update on Pediatric Surveillance Recommendations for PTEN Hamartoma Tumor Syndrome, DICER1-Related Tumor Predisposition, and Tuberous Sclerosis Complex.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Review
  6. DICER1-Related Tumor Predisposition: Identification of At-risk Individuals and Recommended Surveillance Strategies.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 1 country.

Claudette R FraireDepartment of Pediatrics, UT Southwestern Medical Center, Dallas, TX.ORCID 0000-0002-0473-4541
Paige R MallingerInternational Pleuropulmonary Blastoma (PPB)/DICER1 Registry, Children's Minnesota, Minneapolis, MN.
Jessica N HattonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.ORCID 0000-0003-2104-171X
Jung KimDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.ORCID 0000-0001-6274-2841
David S DickensDepartment of Pediatrics, University of Iowa, Iowa City, IA.ORCID 0000-0001-8821-6022
Peter A ArgentaDepartment of Obstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, MN.
Samuel MilanovichPediatric Hematology and Oncology, Sanford Roger Maris Cancer Center, Fargo, ND.
Taylor HartshorneDepartment of Pediatrics, UT Southwestern Medical Center, Dallas, TX.ORCID 0009-0009-2036-9757
David J CareyDepartment of Genomic Health, Geisinger Clinic, Danville, PA.
Jeremy S HaleyDepartment of Genomic Health, Geisinger Clinic, Danville, PA.
Gretchen UrbanDepartment of Genomic Health, Geisinger Clinic, Danville, PA.
Jeon LeeLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX.ORCID 0000-0002-9071-7157
D Ashley HillDepartment of Pathology and Immunology, Washington University, St Louis, MO.ORCID 0000-0003-1067-3922
Douglas R StewartDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.ORCID 0000-0001-8193-1488
Kris Ann P SchultzInternational Pleuropulmonary Blastoma (PPB)/DICER1 Registry, Children's Minnesota, Minneapolis, MN.ORCID 0000-0002-1788-5832
Kenneth S ChenDepartment of Pediatrics, UT Southwestern Medical Center, Dallas, TX.ORCID 0000-0003-2304-4631
Genomic Health (United States) · USNational Institutes of Health · USSouthwestern Medical Center · USChildren’s Minnesota - St. Paul Hospital · USChildren's Medical Center · USFargo VA Health Care System · USUniversity of Iowa · USUniversity of Minnesota · USWashington University in St. Louis · US

Funding

DICER1 and the Pleuropulmonary Blastoma Family Cancer SyndromeR01CA143167 · NCI · CHILDREN'S RESEARCH INSTITUTE · PI HILL, DANA ASHLEY · 2010 to 2020
$3.7M
Detecting DICER1: A global partnership to cure pediatric lung cancerR37CA244940 · NCI · CHILDREN'S HOSPITALS AND CLINICS · PI Kris Ann Pinekenstein Schultz · 2020 to 2026
$2.4M
The role of PLAG1 in Wilms tumor formationK08CA207849 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI CHEN, KENNETH SUNG-MAN · 2017 to 2021
$781k
NCI NIH HHS K08 CA207849NCI NIH HHS R01 CA143167NCI NIH HHS R37 CA244940
6 · The paper itself

Abstract

Germline pathogenic loss-of-function (pLOF) variants in

Indexed as

Ovarian NeoplasmsSertoli-Leydig Cell TumorDEAD-box RNA HelicasesFemaleGerm-Line MutationHumansIntronsMaleMutationRibonuclease IIIDEAD-box RNA HelicasesDICER1 protein, humanRibonuclease III

Identifiers

PMID37883719
PMCPMC10860953
OpenAlexW4387965646

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.